439名40～60岁围绝经期女性脑血管功能测评及影响因素分析

Evaluation of cerebrovascular function and related factors in 439 perimenopausal women aged 40-60 years old

目的了解贵阳市部分40～60岁围绝经期女性脑血管功能情况及影响因素，为围绝经期女性预防脑卒中提供参考。方法采用简单随机抽样，自主设计问卷，对2016年4月至2017年4月于贵州医科大学附属医院健康管理中心接受健康体检的40—60岁无卒中史的围绝经期女性进行问卷调查，测量身高、体重、血压、血脂、血糖、血尿酸，并行脑血管功能检测，比较不同因素对于脑血管功能积分值的影响差异，进而评估卒中风险。结果纳入研究对象439名，脑血管功能积分值异常率（〈75分）占13．2％（58／439）。年龄增长、少数民族、绝经、肥胖、高血压、高血糖、高血尿酸、正常高密度脂蛋白胆固醇（HDL—C）、总胆固醇和三酰甘油升高与脑功能积分值异常有关，差异有统计学意义（P均〈0．05）。经有序Logistic回归分析得出，HDL—C升高[OR（95％CI）：0．38（0．25—0．58），P=0．036]、肥胖[OR（95％C1）：11．62（5．17—26．14），P=0．001]和高血压[0R（95％CI）：14．87（2．46—89．75），P=0．001]是脑血管功能的影响因素。结论围绝经期女性体检者脑血管功能异常率为13．2％。HDL-C升高为围绝经期脑血管功能的保护因素；肥胖与高血压为危险因素，其中高血压对脑血管功能的损伤程度随血压水平升高而加重。

Objective To investigate the assessment and influencing factors of the cerebrovascular function in 40-60 years old women in Guiyang city, and to provide information for the prevention of stroke in menopausal women. Methods Self-designed questionnaire was used among randomly selected healthy women aged 40-60 years who received health checkup from April 2016 to April 2017 in the Medical Examination Center of Affiliated Hospital of Guizhou Medical University. Levels of height, weight, blood pressure, blood lipid, blood glucose, blood uric acid and the cerebral hemodynamics were checked, comparing the influence of different factors for eerebrovascular function integral value differences, and assess the risk of stroke. Results A total of 439 cases were included in the study, the number of cases with abnormal cerebro vascular function （the score of cerebro vascular function score 〈75） accounted for 13.2% （58/439）. Increased age, being ethnic minorities, menopause, obesity, high blood pressure, high blood sugar, high blood uric acid, increased high-density lipoprotein cholesterol （HDL-C）, total cholesterol and triglycerides were related to the abnormal scores of brain function, and the difference was statistically significant （P〈0.05）. Logistic regression analysis indicated that minority, High HDL-C [0R（95% CI）： 0.38 （0.25 - 0.58）, P=0.036], obesity [OR（95 % CI）： 11.62 （5.17- 26.14）, P=0.001 ] and hypertension [OR（95 % CI）： 14.87（2.46-89.75）, P=0.001] are the factors influencing the cerebro vascular function. Conclusion The proportion of abnormal cerebrovascular function was 13.2%. Increased HDL-C is the protective factor for perimenopausal cerebro vascular function. Minority, obesity and high blood pressure are risk factors for cerebro vascular function, of which, the association between hypertension and cerebro vascular function worsens with elevated blood pressure.