血管因素与原发性青光眼相关性的研究进展

The vessel and primary glaucoma

青光眼是一种进行性发展的视神经疾病,为世界范围第一位不可逆性致盲眼病.青光眼的发病机制至今尚未明确.自血管学说提出以来,国内外学者针对青光眼的血管相关因素进行了大量研究,包括血管直径、迂曲程度、位置,血管自主调节能力以及全身性血管因素,然而所得结果均无法阐释青光眼的发病机制.近年来随着血管检测技术的提高,临床获得了一些青光眼发病相关血管因素的新证据,引发了关于青光眼发病机制的新思考.本文针对青光眼血管因素的相关文献进行综述,以期为临床开展相关研究提供参考.

Glaucoma,as the first leading cause of irreversible blindness in the world,is a chronic progressive optic neuropathy.The pathogenesis of glaucoma is still not fully understood till now.A lot of studies about vascular diameter,tortuosity,location,disc perfusion,vascular regulation and systemic vascular factors had been conducted to investigate the relationship between the vascular states and glaucoma since vascular hypothesis proposed.However,direct and convincing evidence for primary mechanisms of glaucoma is still lacking.The development of OCT,especially the Angio-OCT makes the real time visualization and measurement of ocular perfusion in vivo possible,gives some new evidences of vascular dysfunction of optic nerve head associated with glaucoma,which enhancing thinking of the pathogenesis of glaucoma.This review summarizes the literatures on vascular factors associated with glaucoma to provide the references for clinical researches.