非典型抗精神病药物与阿尔茨海默病患者脑血管意外发生的关系研究

Atypical antipsychotics and cerebrovascular accidents in patients with Alzheimer＇s disease

目的研究分析非典型抗精神病药物与阿尔茨海默病（AD）患者脑血管意外发生的相关性。方法选取本院收治的176例阿尔茨海默病患者，给予非典型抗精神病药物治疗，治疗期为3个月，比较治疗前后脑血管意外发生危险因素[平均动脉压、血糖、甘油三酯（TG）]的水平变化，并评价两者的关系。结果治疗1个月脑血管意外的发生率明显低于治疗3个月（17．6％比31．3％，P〈0．05）；治疗前、治疗1个月和3个月平均动脉压呈降低趋势，空腹血糖和TG呈逐渐升高趋势，这3项指标各自比较差异均有统计学意义（均P〈0．05）。结论非典型抗精神病药物会引起阿尔茨海默病患者低血压、高血糖、TG，这些因素均可以导致脑血管意外的发生。

Objective To investigate the relationship between atypical antipsychotics and cerebrovascular accidents in patients with Alzheimer＇s disease. Methods A total of 176 cases of Alzheimer＇s disease in our hospital were given atypical antipsychotic treatment, the treatment period was 3 months, compared the levels of risk factors of cerebrovascular accidents [mean arterial pressure, blood glucose, triglyceride （TG）] before and after treatment, and evaluated the relationship between the two. Results The incidence of cerebrovascular accidents 1 month after treatment was significantly lower than that 3 months after treatment （17.6% vs.31.3%, P〈0.05）; before treatment, 1 month after treatment, 3 months after treatment, mean arterial pressure showed a gradually decreasing trend, fasting blood glucose and TG showed a gradually increasing trend, the three indexes were respectively significantly different （P〈0.05）. Conclusion Atypical antipsychotics can cause low blood pressure, hyperglycemia, and high TG in Alzheimer＇s patients, which can lead to cerebrovascular accidents.