他巴唑联合萘心安治疗甲状腺功能亢进的效果观察

Observation of the efficacy of methimazole combined with metoprolol in the treatment of hyperthyroidism

目的探讨他巴唑联合萘心安治疗甲状腺功能亢进的效果。方法选择本院2015年1月至2016年6月收治的甲状腺功能亢进患者100例，按照随机数字表法分为观察组和对照组，各50例。对照组给予他巴唑片，观察组在对照组用药基础上给予萘心安，观察两组治疗效果。结果观察组和对照组的总有效率分别为92．0％和72．0％，观察组明显优于对照组，差异有统计学意义（P〈0．05）；观察组治疗后TGAb、TPOAb水平分别为（119．7±15．5）IU／ml、（252．6±27．6）IU／ml，对照组分别为（268．1±29．6）IU／ml、（506．1±35．9）IU／ml，观察组较对照组明显下降，差异有统计学意义（P〈0．05）；治疗前两组FT3、FT4水平均差异无统计学意义（P〉0．05）；治疗后，观察组FT3、FT4水平较对照组明显提高，组间比较，差异均有统计学意义（均P〈0．05）；观察组副反应发生率为14．O％，对照组副反应发生率为10．O％，观察组略高于对照组，差异无统计学意义（P〉0．05）。结论他巴唑联合萘心安治疗甲状腺功能亢进的效果显著。

Objective To investigate the efficacy of methimazole combined with metoprolol in the treatment of hyperthyroidism. Methods 100 patients with hyperthyroidism in our hospital from January 2015 to June 2016 were selected and were divided into observation group （50 cases） and control group （50 cases） according to the random number table. The control group was given methimazole tablets, and the observation group was given metoprolol based on the control group. The therapeutic effects of the two groups were observed. Results The total efficiency in the observation group and the control group were 92.0% and 72.0%, that of the observation group was significantly better than that of the control group （P〈0.05）. TGAb, TPOAb levels in the observation group after treatment were （119.7±15.5）IU/ml, （252.6±27.6）IU/ml, those in the control group were （268.1±29.6）IU/ml, （506.1±35.9）IU/ml, those in the observation group were lower than those in the control group （P〈0.05）. There were no statistically significant differences in FT3 and FT4 levels between the two groups before treatment （P〉0.05）; after treatment, FT3, FT4 levels of the observation group were significantly higher that those of the control group, with statistically significant differences （P〈0.05）. The incidence of side effects in the observation group was 14.0%, that in the control group was 10.0%, that in the observation group was slightly higher than in the control group, without statistically significant difference （P〉0.05）. Conclusion The efficacy of methimazole combined with metoprolol in the treatment of hyperthyroidism is significant.