摘要
证实广枣总黄酮(TFC)40.32mg/kg和20.16mg/kg均可明显增强正常和环磷酰胺所致免疫功能抑制小鼠细胞免疫和体液免疫功能。表现为增加免疫器官重量,使溶血素、溶菌酶含量和再次抗原刺激抗体的效价升高,增加淋巴细胞ANAE(+)细胞百分率,促进腹腔巨噬细胞吞噬功能等。
Total flavones were isolated from the fructus of choerospon-dias axillaris(Roxb. )Burrt et Hill ( TFC ) . TFC (40.32 and 20.16 nig/kg?d-1 , ip^5d) strengthened markedly functions of cellulae immunity and humoral immunity in normal mice as well as in immunodepressed mice induced by cyclophsphamide ( 25mg/kg?d-l, ih^2d). TFC caused a significant increase of the weights of spleen and thy-mus, and the production of serum hymolysin in normal and immunodepressed mice.TFC elevated normal titer of antibody induced by secondary antigen stimulation, and increased ANAE ( + ) cell percentage of lymphocyte and phagocytic activity of macrophages of abdominal cavity in normal and immunodepressed mice. TFC increaced the production of serum lysozyme in normal mice.
出处
《中国药理学通报》
CAS
CSCD
北大核心
1991年第3期214-217,共4页
Chinese Pharmacological Bulletin
关键词
广枣
黄酮
环磷酰胺
细胞免疫
Total flavones of Choerospondias axillaris
Cyclophos-phamide
cellular immunity
humoral immunity
Hemolysin
Phagocytic activity of macrophage
