湖南地区孕晚期女性血浆D-二聚体参考区间的建立

Establishment of Reference Intervals of Plasma D-dimer in Women During Third Trimester of Pregnancy in Hunan

【目的】建立湖南地区孕晚期女性血浆D-二聚体的参考区间。【方法】选取2014年1月至2016年3月在湖南省妇幼保健院做产前检查的678例单胎晚孕孕妇、418例双胎/多胎晚孕孕妇为研究对象,以同期208例健康非孕妇女为对照,采用全自动生化分析仪使用免疫比浊法测定其D-二聚体浓度。【结果】晚孕孕妇血浆D-二聚体含量明显高于非孕妇女（P〈0.05）,且双胎/多胎组显著高于同期单胎组（P〈0.05）。孕晚期女性血浆D-二聚体（D-二聚体单位,DDU）的参考区间：单胎组：28-35周,〈3.64 μg/mL;36-39周：〈6.12 μg/mL;40-41周,〈6.84 μg/mL;双胎/多胎组：28-31周,〈6.26 μg/mL;32-35周,〈7.13 μg/mL;36-39周,〈8.00 μg/mL。【结论】本研究初步建立了湖南省孕晚期妇女免疫比浊法血浆D-二聚体参考区间,适宜全省参考应用。

【Objective】To establish reference intervals for D-dimer in women of late pregnancy in Hunan area.【Methods】Six hundred and seventy-eight healthy singleton pregnancy women, 418 healthy twins or multiple pregnancy women（≥28 weeks）and 208 healthy non-pregnant women received Physical Examination in the hospital from January 2014 to March 2016 were selected. Automatic biochemical analyzer was used to detect the concentration of plasma D-dimer（D-dimer unit, DDU） by immune turbidimetric method.【Results】The plasma levels of D-dimer in third trimester of pregnancy were higher than those of non-pregnant women（P〈0.05）, the plasma D-dimer level of twins or multiple pregnancy women was significantly higher than that of the singleton pregnancy women in the same period of time （P〈0.05）. Late pregnant women plasma D- dimer （ D- dimer units, DDU） reference interval： single pregnancy group： 28~35 weeks 〈3.64 μg/mL; 36~39 weeks〈6.12 μg/mL; 40~41weeks〈6.84 μg/mL; twins /multiple pregnancy group： 28~31 weeks〈6.26 μg/mL; 32~35 weeks〈7.13 μg/mL; 36~39 weeks〈8.00 μg/mL.【Conclusion】This study preliminarily established the reference interval of plasma D-dimer by immune turbidimetric method in late pregnancy women in Hunan Province, which is suitable for reference in the whole province.