输血前预防用药对输血反应发生率影响的Meta分析

Meta-analysis of effect of pre-transfusion prophylactic medication on incidence of fever and allergic transfusion reaction

[目的]探讨输血前预防用药对发热及过敏性输血反应发生率的影响。[方法]收集万方数据库、中国知网、维普中文科技期刊数据库、PubMed、Cochrance Library、Clinical Evidence建库至今所发表的有关输血前预防用药的临床对照试验。由2名研究者按照Cochrane系统评价手册Version 5.1质量评价标准进行方法学质量评价,提取数据,并用RevMan 5.2软件进行Meta分析。[结果]最终纳入8篇文献。Meta分析结果显示:输血前预防用药组较输血前未预防用药组发热反应的发生率明显降低,差异有统计学意义[OR=0.75,95%CI(0.58,0.98),P=0.03]。[结论]输血前预防性用药能够降低发热反应的发生率,但不能降低过敏反应的发生率。但结论尚需高质量的随机对照试验(RCT)支持。

Objective：To explore the effect of prophylactic medication before transfusion on the incidence of fever and allergic transfusion reaction.Methods：The database was collected from Wan Fang,CNKI,VIP,PubMed,Cochrance library,Clinical Evidence from inception to now.All the randomized controlled trials（RTCS）of prophylactic medication before transfusion were collected,and data was extracted and evaluated by two researchers based on Cochrane system evaluation manual Version 5.1 quality evaluation criteria for methodological quality assessment.Revman 5.2 software was used for Meta analysis.Results：A total of 8 literatures were enrolled in the study.The results of Meta analysis showed that the incidence of fever in the prophylactic medication group was significantly lower than that in the untreated group before transfusion,and the differences were statistically significant[OR=0.75,95%CI（0.58,0.98）,P=0.03].Conclusion：Pre-transfusion prophylactic medication can reduce the incidence of fever,cannot reduce the incidence of allergic reactions.The conclusion is still need high quality randomized controlled trials support.