通络活血针刺法治疗卵巢早衰临床疗效观察

Clinical effect of tongluo huoxue acupuncture on premature ovarian failure

目的观察通络活血针刺法治疗卵巢早衰的临床疗效。方法选取武警陕西省总队医院自2014年1月至2016年12月收治的60例卵巢早衰患者为研究对象。采用随机数字表法将患者分为A、B组两组,每组各30例。A组患者进行口服克龄蒙治疗,B组患者在A组治疗基础上加用通络活血针刺法治疗。两组均连续治疗3个月,停药后观察3个月,并于治疗前及停药后3个月监测血清促卵泡激素(FSH)、黄体生成素(LH)、雌二醇(E2)水平,观察并记录两组患者的治疗疗效及中医症状积分变化情况。结果 B组治疗总有效率为90.0%(27/30),明显高于A组的63.3%(19/30),组间比较,差异有统计学意义(P<0.05)。停用药物3个月后,两组的中医症状积分与未治疗前比较均明显下降(P<0.05),两组间比较,差异也有统计学意义(P<0.05);两组血清FSH、LH水平均低于治疗前,两组间比较,差异无统计学意义(P>0.05);血清E2水平明显高于治疗前,两组间比较,差异有统计学意义(P<0.05)。结论针刺在改善卵巢早衰患者E2水平及中医症状方面均有一定的疗效,在改善FSH方面尚待于进一步研究。

Objective To investigate the clinical effect of self-made tongluo huoxue acupuncture on premature ovarian failure（ POF）.Methods A retrospective study was performed on 60 cases of patients who were diagnosed as POF and were admitted from January2014 to December 2016. Patients were randomly divided into Group A and Group B,with 30 cases in each group. Patients in Group A were given oral climen treatment,the others in Group B were given tongluo huoxue acupuncture on the base of the treatment of Group A. The patients of the two groups were treated for continuous 3 months,and were observed after the treatment for 3 months. Before the treatment and 3 months after the drug was stopped,the serum follicle stimulating hormone（ FSH）,luteinizing hormone（ LH） and estradiol（ E2） levels were observe and the treatment efficacy of two groups of patients and TCM symptom score changes were recorded.Results The total effective rate in Group B was 90. 0%（ 27/30）,which was significantly higher than that in Group A,which was63. 3%（ 19/30）（ P〈0. 05）. After 3 months of discontinuation of the drug,both groups of TCM symptoms were significantly lower than those before treatment,and the differences between the two groups were statistically significant（ P〈0. 05）. The levels of FSH and LH in both groups were significantly lower than those before treatment,and there was no statistically significant difference between the two groups（ P〉0. 05）. Serum E2 levels were significantly higher than those before treatment,and the differences between the two groups were statistically significant（ P〈0. 05）. Conclusion Acupuncture has a certain effect on the improvement of premature ovarian estradiol levels,and further research is still pending in the improvement of FSH.