摘要
以1-苯基-6,7-二氢-1H-吲唑-4(5H)-酮和取代芳香醛为原料,在碱性条件下缩合得到5-芳亚甲基-1-苯基-6,7-二氢-1H-吲唑-4(5H)-酮,再与腈氧化物进行1,3-偶极环加成得到系列4'-(4-芳基)-3'-(2,6-二氯苯基)-1-苯基-6,7-二氢-4'H-螺[吲唑-5,5'-异噁唑]-4(1H)-酮新化合物,采用NMR、IR、MS以及元素分析表征其结构。
The condensation of 1-phenyl-6,7-dihydro-lH-indazol-4 (5H)-one and substituted aromatic aldehyde yielded 5-arylmethylene-l-phenyl-6,7-dihydro-lH-indazol-4 (5H)-one under alkaline condition. The 1,3-dipolar cyeloaddition of nitrile oxide to these materials acquired above afforded a series of novel 4'-(4-aryl)-3'-(2,6- dichlorophenyl)-1-phenyl-6,7-dihy-dro-4'H-spiro[indazole-5,5'-isoxa-zol]-4(1H)-ones. The structures of all the products were characterized by NMR, IR, MS together with elemental analysis.
作者
刘秋华
旷国强
唐子龙
LIU Qiu-hua KUA NG Guo-qiang TANG Zi-long(School of Chemistry and Chemical Engineering, Key Laboratory of Theoretical Organic Chemistry and Function Molecule of Ministry of Education, and Hunan Provincial Key Laboratory of Controllable Preparation and Functional Application of Fine Polymers, Hunan University of Science and Technology, Xiangtan 411201, China)
出处
《精细化工中间体》
CAS
2017年第4期18-24,共7页
Fine Chemical Intermediates
基金
国家自然科学基金青年项目(21602054)
关键词
螺杂环
1
3-偶极环加成
腈氧化物
异噁唑
spiroheterocycle
1,3--dipolar cycloaddition
nitrile oxide
isoxazole