头孢克肟E-异构体的合成和确证

Synthesis of Cefixime(E)-Isomer

以(E)-2-(2-氨基-4-噻唑)-2-(甲氧羰基甲氧亚胺基)乙酸(反式MICA)为起始原料,与促进剂DM进行酯化反应后,再与7-氨基-3-乙烯基-3-头孢烯-4-羧酸(AVNA)进行酰化反应、水解得到头孢克肟E-异构体,总收率达57.7%;并基于1H NMR、13C NMR和IR等谱图对合成的头孢克肟E-异构体进行了结构确证。

A cefixime E-isomer was obtained using （E）-2-（2-Amino-4-thiazole）-2-（methoxycarbony lmethoxyimino） acetic acid （trans MICA） as the starting material. The preparation process included a esterification reaction with DM followed by acylation reaction with 7-amino-3-vinyl-3-eephem-4-earboxylic acid （AVNA） and a final hydrolysis reaction with a total molar yield of 57.7%. The structure of the final product was confirmed.