联合检测血清铁蛋白和甲胎蛋白对原发性肝癌的诊断价值

COMBINATIVE TESTS OF SERUM FERRITIN AND ALPHA-FETOPROTEIN IN THE DIAGNOSIS OF PRIMARY HEPATOCELLULAR CANCER

目的 :探讨联合检测血清铁蛋白和甲胎蛋白对原发性肝癌的诊断价值。方法 :分别用免疫透射比浊法和发光免疫法测定 2 8例原发性肝癌 ,19例肝硬化患者和 35例健康对照者的血清铁蛋白和甲胎蛋白。结果 :原发性肝癌组与肝硬化组、健康对照组相比 ,血清铁蛋白和甲胎蛋白均明显升高 (P <0 .0 1,P <0 .0 1) ,在原发性肝癌患者中 ,血清铁蛋白的阳性率为 6 0 .7% ,特异性为 90 .7% ,甲胎蛋白的阳性率为 71.4 % ,特异性为96 .3% ,两者联合的阳性率为 92 .9% ,特异性为 87.0 %。结论 :血清铁蛋白、甲胎蛋白联合检测 ,可提高肝癌的诊断阳性率 。

Objective:To elucidate the significance of the combinative tests of serum ferritin(SF) and alpha-fetoprotein (AFP) of primary hepatocellular cancer.Methods:Ferritin and alpha-fetoprotein in the serum were determined by nepelometry immunology and chemiluminessant immunoassay respectively, in 28 patients with primary hepatocellular cancer, 19 patients with liver cirrhosis and 35 healthy subjects. Results:The levels of SF and AFP increased apparently in primary hepatocellular cancer ( P <0.01, P< 0.01). The diagnostic rate of serum ferritin was 60.7% in primary hepatocellular cancer and its sensitivity was 90.7%. The diagnostic rate of alpha-fetoprotein was 71.4% and its sensitivity was 96.3%.The combination of the two tests raised the diagnostic rate to 92.9% and lowered the sensitivity to 87.0%.Conclusions:These results indicate that the combination of SF and AFP measurement is useful for the diagnosis of primary hepatocellular cancer.