摘要
目的:探讨一贯煎合二至丸加减方治疗更年期尿道综合征的临床疗效。方法:120例患者随机分为两组。中药治疗组60例,给予一贯煎合二至丸加减方治疗,对照组60例,给予尼尔雌醇口服治疗,两组疗程均为12周。观察两组患者症状积分、临床疗效、免疫功能及性激素的变化,观察药物不良反应。结果:治疗12周后,中药治疗组症状积分显著低于对照组(P<0.01);中药治疗组总有效率78.33%,显著高于对照组55.0%(P<0.01);中药治疗组Ig A、Ig G、Ig M含量均明显高于对照组(P<0.01,P<0.05);两组患者治疗前后E2、FSH水平比较均无统计学差异(P>0.05);两组患者均无明显不良反应。结论:一贯煎合二至丸加减方治疗更年期尿道综合征,能够有效减轻临床症状,提高临床疗效,增强免疫功能,同时还具有类似雌激素的作用,安全性良好,值得推广。
Objective:To explore the clinical efficacy of modification of Yiguan Decoction combining with Erzhi Pills in treating climacteric urethral syndrome.Methods:Totally 120 patients were randomly divided into two groups.Sixty cases were included into the traditional Chinese medicine(TCM) group and were treated with modification of Yiguan Decoction combining with Erzhi Pills.The remaining 60 cases were included into the control group and were given nilestriol peroral treatment.The treatment course of the two groups was 12 weeks.The symptom score,clinical efficacy,immune function,the changes of sex hormones and adverse drug reactions of the two groups were observed.Results:After 12 weeks of treatment,the symptom score of TCM group was significantly lower than that of the control group(P〈0.01).The total efficiency of the TCM group was 78.33%,which was significantly higher than that of the control group(55.0%)(P〈0.01).The amounts of Ig A,Ig G and Ig M of TCM group were significantly higher than those of the control group(P〈0.01,P〈0.05).Before and after treatment,there was no significant difference in levels of E2 and FSH of the two groups(P〈0.05).Patients of the two groups had no obvious adverse reactions.Conclusion:Modification of Yiguan Decoction combining with Erzhi Pills in treating climacteric urethral syndrome can effectively relieve the clinical symptoms,improve the clinical efficacy and enhance the immune function.At the same time,the treatment has similar effect with estrogen.The security is good and so it is worthy of popularizing.
作者
冯继伟
冯硕
FENG Jiwei FENG Shuo(Gongli Hospital,Shanghai Pudong New Area,Shanghai 200135, China School of Medicine, Shanghai Jiao Tong University, Shanghai 200001, China)
出处
《辽宁中医杂志》
CAS
北大核心
2017年第10期2108-2111,共4页
Liaoning Journal of Traditional Chinese Medicine
基金
上海市卫生局中西医融合发展基金资助项(ZY3-CCCX-3-7001)
关键词
一贯煎
二至丸
更年期
尿道综合征
Yiguan Decoction
Erzhi Pills
climacteric
urethral syndrome