中医药方剂在晚期肝癌患者疼痛减轻和生存期延长方面的作用

Effects of Traditional Chinese Medicine Prescriptions on Relieving Pain and Prolonging Survival of Patients with Advanced Liver Cancer

目的:探讨中医药方剂的运用在晚期肝癌患者疼痛减轻和生存期延长方面的作用。方法:选取89例晚期肝癌患者,按照病人治疗意愿分成两组,对照组35例,观察组54例;对照组予以止痛等减症支持治疗,观察组在对照组的基础上予以中医药方剂辨证治疗;患者疼痛情况主要以患者主观感受和疼痛视觉模拟(VAS)评估,分别记录两组患者给药前、后VAS评分和患者肝功能指标及1月、2月、3月生存率。结果:两组患者治疗后疼痛均有显著减轻(P<0.05),但观察组治疗后第1月时VAS评分为(5.7±1.2)显著低于对照组,P<0.05,差异显著,具有统计学意义;统计两组生存率及生存时间,观察组在1月、2月、3月时的生存率分别是88.89%、75.95%、66.67%均显著高于对照组,P<0.05,差异具有统计学意义;比较治疗前、后1个月时两组患者部分肝功能指标(ALT、AST、Tb)及甲胎蛋白(AFP),治疗后两组指标均有下降,观察组ALT(93.2±11.5)U/L、AST(96.5±13.8)U/L、Tb(54.3±4.7)μmol/L、AFP(705±203)μg/L均低于对照组,P<0.05,差异显著,具有统计学意义。结论:中医药方剂可有效减轻肝癌晚期患者的疼痛,普遍延长生存期。

Objective：To explore the effect of traditional Chinese medicine prescription on pain relief and survival of patients with advanced liver cancer.Methods：Eighty-nine patients with advanced hepatocellular carcinoma were divided into 2 groups according to the patients＇ treatment intention,35 cases in the control group and 54 cases in the observation group.In the control group,the patients were treated with the analgesic and so on,and the observation group was treated by traditional Chinese medicine prescription.The patients＇ pain was evaluated by VAS.The VAS score,liver function index before and after the treatment and survival rates of 1st month,2nd month,3rd month after treatment were recorded.Results：The VAS scores of the two groups were significantly reduced after treatment（P〈0.05）,but the VAS score of the observation group was（5.7±1.2） in the first month after treatment,significantly lower than that of the control group,P〈0.05.The difference was significant in statistics.The survival rates of the observation group were 88.89%,75.95% and 66.67% respectively,which were significantly higher than those of the control group（P〈0.05）.The difference was statistically significant（P〈0.05）.Compared the liver function index（ALT,AST,Tb） and alpha-fetoprotein（AFP） in the two groups before and after treatment,the indexes of the two groups decreased after treatment,especially the observation group＇s ALT（93.2±11.5） U/L,AST（96.5±13.8） U/L,Tb（54.3±4.7） μmol/L and AFP（705±203） μg/L were significantly lower than those of the control group,P〈0.05.The difference was statistically significant.Conclusion：Traditional Chinese medicine prescription can effectively relieve pain in patients with advanced liver cancer and generally prolong the survival period.