桃核承气汤治疗男性阴虚湿热证前列腺炎的疗效观察

Curative Effect of Taohe Chengqi Decoction of Yin Deficiency and Dampness Heat Syndrome of Prostatitis

目的:探讨桃核承气汤治疗男性阴虚湿热证前列腺炎的疗效。方法:选择2014年5月—2016年5月本院接诊86例阴虚湿热证前列腺炎患者,通过随机数表法分为观察组和对照组,各43例。对照组给予前列康+盐酸左氧氟沙星胶囊的口服,观察组在对照组的基础上,联合使用桃核承气汤。治疗4周后,评价治疗效果。结果:治疗后,观察组前列腺体积小于对照组,残余尿量小于对照组,最大尿流率大于对照组[(2.08±0.13)cm3vs(2.65±0.18)cm3,(27.41±4.53)mL vs(34.98±6.87)mL,(20.82±3.46)mL/s vs(15.83±2.50)mL/s](P<0.05);观察组白细胞介素-6(IL-6)、IL-8、肿瘤坏死因子(TNF-α)水平均低于对照组[(1.14±0.25)μg/L vs(1.46±0.30)μg/L,(6.54±1.10)μg/L vs(9.85±1.58)μg/L,(41.32±8.54)ng/L vs(53.09±11.34)ng/L](P<0.05);观察组美国国立卫生研究院慢性前列腺炎症状积分指数(NIHCPSI)总分低于对照组[(9.46±1.76)分vs(16.89±2.86)分](P<0.05);观察组临床疗效总有效率高于对照组[97.67%(42/43)vs79.07%(34/43)](P<0.05);治疗过程中,观察组不良反应发生率低于对照组[2.33%(1/43)vs13.95%(6/43)](P<0.05)。结论:在阴虚湿热证前列腺炎患者常规西医治疗基础上,联合应用桃核承气汤治疗效果显著,可有效缓解临床症状,促进病情恢复,值得应用推广。

Objective：To study effect of Taohe Chengqi Decoction of yin deficiency and dampness heat syndrome of prostatitis.Methods：A total of 86 patients with syndrome of yin deficiency and damp-heat prostatitis from May 2014 to May 2016 in our hospital were researched.They were randomly divided into observation and control groups,each 43 cases.The control group was given prostate ＋ levofloxacin hydrochloride capsules orally.After 4 weeks of treatment,the therapeutic effect was evaluated.Results：After treatment,the prostate volume of the observation group was smaller than that of the control group and the residual urine volume was less than that of the control group.The maximum urinary flow rate was greater than that of the control group[（2.08±0.13）cm3vs（2.65±0.18） cm3,（27.41±4.53） mL vs（34.98±6.87） mL,（20.82±3.46） mL/s vs（15.83±2.50） mL/s]（P〈0.05）.The interleukin-6（IL-6）,IL-8,tumor necrosis factor（TNF-α） levels of the observation group were lower than those of the control group[（1.14±0.25） μg/L vs（1.46±0.30） μg/L,（6.54±1.10） μg/L vs（9.85±1.58） μg/L,（41.32±8.54） ng/L vs（53.09±11.34） ng/L]（P〈0.05）.The total score of United States National Institutes of Health Chronic Prostatitis Symptom Index（NIHCPSI） in the observation group was lower than that in the control group[（9.46±1.76） score vs（16.89±2.86） score]（P〈0.05）.The total effective rate of observation group was higher than that of control group[97.67%（42/43） vs 79.07%（34/43） ]（P〈0.05）.During the treatment,the incidence of adverse reactions in the observation group was lower than that of the control group[2.33%（1/43） vs 13.95%（6/43） ]（P〈0.05）.Conclusion：On the basis of conventional western medicine treatment of prostatitis patients with syndrome of yin deficiency and damp-heat,the combined application of Taohe Chengqi Decoction has significant effect can effectively alleviate the clinical symptoms and promote the recovery of the disease.It＇s worthy of application and promotion.