摘要
目的 评价用帕尼培南 /倍他米隆治疗肺部感染的有效性及安全性。方法 2 0例肺部感染患者使用帕尼培南 /倍他米隆 5 0 0 /5 0 0mg,每 12h1次 ,静脉点滴 ,疗程 3～ 7d治疗。通过细菌培养、检测血药浓度动态变化 ,以探讨帕尼培南 /倍他米隆对肺部感染患者的适用价值。结果 致病菌阴转率为 77.8% ,治疗有效率为 75 % ,未出现明显不良反应 ;血药峰值浓度为 (30 .2 5±5 .4 3)mg/L ,用药 6h后血药浓度为 (0 .6 6± 0 .34)mg/L ,血分布半衰期为 (0 .34± 0 .18)h ,血消除半衰期为 (1.4 2± 0 .31)h。结论 帕尼培南 /倍他米隆对肺部感染有较好疗效 。
Objective To estimate the clinical significance and safety of panipenem/betamipron in treating pulmonary infection. Metheods 20 cases of pulmonary infection were treated with panipenem/betamipron 500/500mg every 12h intravenously, bacterial cultrue was conducted and panipenem concentration in plasma was consecutively measured. Results Results showed that the eradication rate of bacteria was 77.8% and the effective healing rate of panipenem was 75% respectively; no adverse drug reaction appeared; the peak value of panipenem in plasma was 29.47±0.99mg/ml and it was decreased to 2.44±0.90g/m1 6h later, the half life of distribution and elimination of panipenem in plasma was 0.34±0.18h and 1.42±0.31h respectively. Conclusion Panipenem/betamipron is effective and safe for treatment of pulmonary infection
出处
《重庆医学》
CAS
CSCD
2002年第9期789-791,共3页
Chongqing medicine
