尿毒清颗粒联合饮食干预对慢性肾功能衰竭患者血清Chemerin、VEGF的影响

Effect of Niaoduqing particles combined with diet intervention on serum chemerin and VEGF in patients with chronic renal failure

目的探讨尿毒清颗粒联合饮食干预治疗慢性肾功能不全患者的疗效以及对血清脂肪因子趋化素(Chemerin)和血管内皮生长因子(VEGF)水平的影响。方法选择2014年1月至2016年2月在我院肾脏内科住院治疗的慢性肾功能衰竭患者40例,随机分为2组。对照组20例,接受常规治疗及普通低蛋白饮食;观察组20例,在常规治疗基础上加用尿毒清颗粒及个体化低蛋白饮食干预。疗程为4周。于治疗前、治疗4周后检测Chemerin、VEGF水平,比较两组疗效。结果治疗后,观察组有效率(90.0%)明显高于对照组(55.0%),差异有统计学意义(χ~2=6.468,P=0.039);两组患者尿素氮(BUN)、血肌酐(Scr)均明显降低(P<0.01),内生肌酐清除率(Ccr)显著升高(P<0.05或P<0.01);观察组BUN、Scr、Ccr改善程度优于对照组(P<0.05);两组血清Chemerin、VEGF水平明显减低(P<0.05或P<0.01),观察组血清Chemerin、VEGF水平明显低于对照组(t=2.113,P=0.041;t=2.350,P=0.024);血清Chemerin与VEGF水平呈正相关(r=0.473,P=0.002)。结论尿毒清颗粒联合饮食干预治疗CRF临床疗效确切,能改善患者肾功能,且能有效降低血清Chemerin、VEGF水平。

Objective To explore the efficacy of Niaoduqing particles combined with diet intervention on serum chemerin and vascular endothelial growth factor（ VEGF） in the patients with chronic renal failure（ CRF）. Methods Forty inpatients with CRF from January 2014 to February 2016 were enrolled and randomly divided into two groups. Control group（ n = 20） was given regular treatment and normal low-protein diet,while observation group（ n =20） was given Niaoduqing particles and individualized low-protein diet intervention on the basis of regular treatment for4 weeks. The curative effect was compared between the two groups. Serum chemerin and VEGF were detected and compared before and after 4-week treatment. Results After treatment, the effective rate in observation group was higher than that of control group（ 90% vs. 55%,χ～2 = 6. 468,P = 0. 039）; the serum urea nitrogen（ BUN） and creatinine（ Scr） of patients were decreased after treatment（ P〈0. 01）,while the endogenous creatinine clearance rate（ Ccr） was increased（ P〈0. 05 or P〈0. 01）, and there were significant differences between the two groups（ P〈0. 05）; the levels of serum chemerin and VEGF in both groups were significantly decreased after treatment（ P〈0. 05 or P〈0. 01）, and the levels of the indexes in observation group were lower than those of conrol group（ t = 2. 113,P = 0. 041; t = 2. 350,P = 0. 024）. Serum chemerin was positively correlated with VEGF（ r = 0. 473,P = 0. 002）. Conclusion Niaoduqing combined with diet intervention is effective in the treatment of CRF,which can improve the renal function, and effectively decrease the serum levels of chemerin and VEGF.