艾滋病患者T淋巴细胞水平与中医证型关系研究

Correlation Study on T Lympholyte Level and Traditional Chinese Medicine Types of AIDS Patients

目的:观察艾滋病患者肺气虚弱证和肺脾气虚证与T淋巴细胞之间的相关性。方法:选取艾滋病肺气虚弱证患者34例,肺脾气虚证患者68例作为研究对象,运用流式细胞仪检测不同证型患者T淋巴细胞亚群水平,分析中医证型与T淋巴细胞亚群的相关性。结果:肺气虚弱证患者CD_3^+T淋巴细胞为(1 547.12±807.909)mm^(-3),肺脾气虚证患者CD_3^+T淋巴细胞为(1 213.09±580.928)mm^(-3),两组比较,差异有统计学意义(P=0.019<0.05);肺气虚弱证患者CD_8^+T淋巴细胞为(1 090.59±632.818)mm^(-3),肺脾气虚证患者CD_8^+T淋巴细胞为(860.06±456.800)mm^(-3),两组比较,差异有统计学意义(P=0.038<0.05);CD_4^+方面,肺脾气虚证患者的平均秩次为47.13,肺气虚弱证患者的平均秩次为60.24,两组比较,差异有统计学意义(P=0.035<0.05);CD_4^+/CD_8^+方面,肺脾气虚证患者平均秩次为50.43,肺气虚弱证患者平均秩次为53.65,两组比较,差异无统计学意义(P=0.604>0.05)。结论:艾滋病肺脾气虚证患者淋巴细胞下降更显著,免疫功能损伤更严重,更容易出现机会性感染。

Objective： To observe AIDS pulmonary Qi weakness and pulmonary-spleen deficiency and its correlation with T lymphocytes. Methods： Through collecting information table of syndromes of lung Qi weakness（ 34 cases） and lung-spleen Qi deficiency（ 68 cases）,using flow cytometry instrument detection of T lymphocyte subsets,using SPSS statistical AIDS pulmonary Qi weakness and pulmonary-spleen Qi deficiency and its correlation with T lymphocyte subsets. Results： Qi deficiency in patients with CD_3~＋T lymphocytes（ 1 547. 12 ± 807. 909） mm-3,CD_3~＋T lymphocytes with lung and spleen Qi deficiency syndrome was（ 1 213. 09 ±580. 928） mm^（-3）,the difference was statistically significant（ P = 0. 019 〈0. 05）; Qi deficiency in patients with CD_8~＋T lymphocytes（ 1 090. 59 ± 632. 818） mm^（-3）,CD_8~＋T lymphocytes in patients with lung-spleen Qi deficiency syndrome for（ 860. 06 ±456. 800） mm-3,between the two groups,the difference was statistically significant（ P = 0. 038〈 0. 05）; in CD_4~＋,patients with lung-spleen Qi deficiency syndrome,the mean rank of 47. 13,patients with pulmonary Qi deficiency syndrome of the average rank was 60. 24,the difference was statistically significant（ P = 0. 035 〈0. 05）; in CD_4~＋/CD_8~＋,lung spleen Qi deficiency syndrome with the average rank was 50. 43 in patients with pulmonary Qi deficiency syndrome,the average rank was 53. 65,the difference was not statistically significant（ P = 0. 604 〉0. 05）. Conclusion： The lymphocytes in HIV/AIDS patients of lung spleen Qi deficiency syndrome decreasing more significantly,the immune function damage is more serious,more vulnerable to opportunistic infections.