血浆鸢尾素水平与2型糖尿病及体力活动的关系研究

Association of plasma irisin level with prevalence of type 2 diabetes mellitus an_d phYsical acti^ty

选取186例2型糖尿病患者（DM组）和72名健康体检者（NDM组），测定其各生化指标、血浆鸢尾素浓度，并评估其活动强度和活动时长，按照血浆鸢尾素浓度四分位数将所有研究对象分为4组，比较4组间2型糖尿病的患病比例，研究DM组血浆鸢尾素浓度与体力活动之间的关系。结果显示，血浆鸢尾素浓度与2型糖尿病患病比例负相关（OR=0.984，95%CI 0.973-0.996）。DM组血浆鸢尾素浓度与年龄（r=-0.227, P=0.029）、血尿酸（r=-0.225, P=0.032）水平呈负相关。业余体育锻炼时长达到4级时，业余体育锻炼强度对DM组血浆鸢尾素浓度有统计学意义上的影响（χ^2=7.319，P=0.025）。排除了年龄、相关生化指标、工作强度和相应的工作时长等因素后，DM组的血浆鸢尾素浓度与业余体育锻炼强度正相关（β=0.326，P=0.014）、与相应的体育锻炼时长负相关（β=-0.454，P=0.001）。提示血浆鸢尾素浓度升高则2型糖尿病患病比例下降；每周5-7次、每次1 h的中等强度运动和短时间高强度的运动能够增加血浆鸢尾素的水平。

A total of 186 type 2 diabetic patients （ DM group） and 72 healthy subjects （NDM group） were enrolled. Metabolic parameters and serum irisin levels were measured. The effects of intensity and time of the physical activity were evaluated. According to quartiles of plasma irisin levels, all subjects were divided into four groups and the prevalence of type 2 diabetes mellitus （T2DM） among four groups was compared. The relationship between plasma irisin level and physical activity in DM group was investigated. The results showed that plasma irisin levels were correlated negatively with the prevalence of T2DM （OR=0.984, 95%CI 0.973-0.996）; also negatively correlated with age （r=-0.227, P=0.029） and blood uric acid （r=-0.225, P=0.032） in the DM group. When corresponding exercise time was up to grade 4, the intensity of exercise would influence the irisin levels （χ2=7.319, P=0.025）. After controlling for potential confounders such as age, metabolic parameters, intensity of work, timing of work, plasma irisin levels in DM group were correlated positively with the intensity of exercise （β=0.326, P=0.014） and negatively with corresponding exercise time （β=-0.454, P=0.001）. These results suggest that the prevalence of T2DM decreases with the increase of plasma irisin level. Plasma irisin levels are increased after moderate intensity exercise （5-7 times weekly and 1h each time） or by short-term high-intensity exercise.