岗藿抗感汤治疗流感临床疗效观察及其对RIG-I、Th1/Th2影响

Clinical Curative Effect of Ganghuo Kanggan Decoction to Treat Influenza and Its Effect on Th1/Th2 and RIG-I

目的:研究岗藿抗感汤对流感患者临床症状及调节免疫的影响。方法:本研究选择流感患者60例,随机分为岗藿抗感汤组30例、磷酸奥司他韦胶囊组(可威)30例。通过使用岗藿抗感汤治疗流行性感冒,并对患者进行感冒症状分级量化评分及测定患者外周血RIG-I(IFN-α、IFN-β)、Th1/Th2(IFN-γ/IL-4)细胞比值表达,从而了解岗藿抗感汤在流行性感冒发生发展中如何参与调节免疫及对临床症状的影响,为指导临床治疗提供依据。结果:岗藿抗感汤组连续给药5 d,可缩短患者退热时间,改善其感冒症状,升高RIG-I(IFN-α、IFN-β)(P<0.05),也对增高的IFN-γ及IFN-γ/IL-4比值有降低作用(P<0.05)。结论:岗藿抗感汤具有抑制流感病毒Th1细胞亚群优势反应的作用,同时可激活RIG-I诱导I型干扰素的产生,抑制流感病毒的复制。

Objective ：To observe clinical curative effect of Ganghuo Kanggan Decoction to treat influenza and how to modulate immune. Methods ：To select 60 patients with influenza,and then divided into randomly,Ganghuo Kanggan Decoction group of 30 cases and oseltamivir phosphate capsules group of 30 cases（Kewei）. This research used Ganghuo Kanggan Decoction to treat influenza,and recorded the scores of symptoms in patients with influenza and determined the expression of RIG-I（IFN-α,IFN-β）and cell ratio of Th1/Th2（IFN-γ/IL-4）in peripheral blood of patients. The purpose of this study was to understand Ganghuo Kanggan Decoction how to participate in immune regulation and effect of clinical symptoms in influenza development and it provided the basis for guiding clinical treatment. Results ：Ganghuo Kanggan Decoction group was administered continuously for 5 days,could shorten time to bring down a fever of patients,and improved the symptoms of a cold,and also elevated RIG-I（IFN-α,IFN-β）（P0.05）,and decreased increased the IFN-γ and IFN-γ/IL-4 ratio（P0.05）. Conclusion ：Ganghuo Kanggan Decoction could inhibit Th1 lymphocyte subsets dominant reaction of the influenza virus,and also activate the RIG-I induction of type I interferon production to inhibit replication of the influenza virus.