疏肝解郁治则对围绝经期睡眠障碍(焦虑抑郁型)心理及BDNF影响

Effect of Shugan Jieyu Method on Psychological and BDNF of Perimenopausal Sleep Disorder (Anxiety and Depression)

目的:探讨疏肝解郁治则对围绝经期睡眠障碍(焦虑抑郁型)心理及BDNF的影响。方法:选取我院妇科2015年6月—2016年7月收治符合纳入标准的围绝经期睡眠障碍(焦虑抑郁型)患者90例,按随机数字表法分为对照组和研究组,分别45例,对照组予佐匹克隆治疗;研究组在佐匹克隆上予疏肝解郁胶囊治疗,共治疗4周为1个疗程,治疗前后采血测定血清性激素以及实验室相关指标,记录临床相应评分和临床症状评定,同时对比临床疗效及不良反应状况。结果:与治疗前比较,两组治疗后PSQI评分、HAMA评分、HAMD评分降低,失眠多梦、心烦易怒、胁痛、善太息评分降低,血清E2、P升高,FSH降低,血清5-HT、NPY、SP、BDNF含量升高(P<0.05);与对照组比较,研究组治疗后PSQI评分、HAMA评分、HAMD评分较低,失眠多梦、心烦易怒、胁痛、善太息评分较低,血清E2、P较高,FSH较低,血清5-HT、NPY、SP、BDNF含量较高(P<0.05);对照组有效率73.33%与研究组有效率91.11%数据对比,研究组高于对照组(P<0.05);两组仅存在轻微胃肠道反应,经对症处理后症状消失。结论:疏肝解郁治则对围绝经期睡眠障碍(焦虑抑郁型)的疗效确切,改善焦虑、抑郁情绪,提高BDNF含量,值得推广。

Objective ：To study the effect of Shugan Jieyu method on the psychological and BDNF of sleep disorders（anxiety and depression）in perimenopausal period. Methods ：90 patients with perimenopausal sleep disorder（anxiety and depression）were enrolled in our department from June 2015 to July 2016 were divided into control group and study group according to the method of random number table. The control group was treated with zuopiclone,and the study group was treated more with Shugan Jieyu Capsule for 4 weeks. Serum sex hormones were measured before and after treatment,and laboratoryrelated indexes were recorded. Clinical scores and clinical symptoms were recorded,while clinical efficacy and adverse reactions were compared. Results ：Compared with before treatment,PSQI score,HAMA score,HAMD score,scores of insomnia,dysphoria,irritability,hypochondriac pain and hypothyroidism decreased in 2 groups after treatment,levels of serum E2 and P increased,levls of FSH decreased,levels of serum 5-HT,NPY,SP,BDNF increased（P〈0.05）. Compared with the control group,the scores of PSQI,HAMA,HAMD,insomnia,dysphoria,irritability,hypochondriac pain and goodness of the study group were significantly higher（P〈0.05）,levels of serum E2,P were higher,levels of FSH were lower,the effective rate of the control group 73.33% was lower than the study group 91.11%（P〈0.05）,the serum levels of 5-HT,NPY,SP and BDNF were higher（P〈0.05）. There was only slight gastrointestinal reaction in the two groups,and the symptoms disappeared after symptomatic treatment. Conclusion ：Shugan Jieyu method was effective in improving the anxiety and depression,improving the content of BDNF in perimenopausal sleep disorders（anxiety and depression）,and worthy of promotion.