摘要
目的:探讨滋肾清利法对反复发作性尿路感染血清α_1-MG、β_2-MG及细胞免疫的影响。方法:选取辽宁中医药大学附属医院泌尿外科尿路感染患者90例,随机分为两组,各45例。对照组予以常规治疗;研究组在常规治疗上予以滋肾清利法治疗,采血测定血清免疫功能、细胞因子、实验室相应指标,同时对比临床疗效及并发症。结果:与治疗前比较,两组治疗后IgM、IgG、IgA含量升高,CD4、CD4/CD8含量升高,CD8含量降低,血清MCP-1、TNF-α、IL-6、IL-8含量降低,血清α_1-MG、β_2-MG含量降低(P<0.05);与对照组比较,研究组治疗后IgM、IgG、IgA含量较高,CD4、CD4/CD8含量较高,CD8含量较低,血清MCP-1、TNF-α、IL-6、IL-8含量较低,血清α_1-MG、β_2-MG含量较低(P<0.05);对照组有效率73.33%低于研究组有效率91.11%(P<0.05)。结论:滋肾清利法对反复发作性尿路感染疗效确切,提高免疫功能,降低血清α_1-MG、β_2-MG指标,安全性高。
Objective :To investigate the effects of Zishen Qingli method in the treatment of recurrent urinary tract infection in serum α_1-MG,β_2-MG and cellular immunity. Methods :Ninety patients with urinary tract infection in department of urology surgery in affiliated hospital of Liaoning university of traditional Chinese medicine were randomly divided into 2 groups(n=45). Control group received conventional therapy,study group received more with Zishen Qingli method. The serum immune function,cytokines and laboratory indexes were compared after the treatment. Results :Compared with before treatment,the levels of IgM,IgG,IgA in 2 groups after the treatment incerased,levels of serum CD4,CD4/CD8 increased,levels of CD8 decreased,levels of MCP-1,TNF-α,IL-6 and IL-8 decreased,levels of α_1-MG,β_2-MG decreased(P0.05),compared with the control group,the levels of IgM,IgG and IgA in the study group were higher,levels of serum CD4,CD4/CD8 were higher,levels of CD8 were lower,levels of serum MCP-1,TNF-α,IL-6 and IL-8 were lower and the levels of α_1-MG and β_2-MG were lower(P0.05),and the efficient rate in the control group(73.33%)was lower than the study group(91.11%),(P0.05). Conclusion :Zishen Qingli method has definite therapeutic effect on recurrent urinary tract infection,it can improve immune function and lowers serum α_1-MG and β_2-MG indexes with high safety.
出处
《辽宁中医药大学学报》
CAS
2017年第10期147-150,共4页
Journal of Liaoning University of Traditional Chinese Medicine
基金
辽宁省教育厅科研项目(L2010312)