纤毛内转运蛋白20的研究进展

Advances of intraflagellar transport protein 20 in current research

纤毛内转运蛋白20(intraflagellar transport protein 20,IFT20)是细胞纤毛内转运蛋白B类中的一种,定位于高尔基体,在纤毛内蛋白转运、纤毛组装和维持纤毛正常形态等多种生理功能的调节中具有关键性作用。IFT20的异常表达与肿瘤、多囊肾、免疫紊乱等多种疾病的发生有关,可能是一些重大疾病防治的分子靶点。

intraflagellar transport protein 20 （IFT20） is one kind of protein of intraflagellar transport B complex, mainly located in golgi body. IFT20 plays a pivotal role in transporting molecular motors, assembling and maintaining cilia. The defection of IFT20 may cause various diseases including cancer,polycystic kidney disease and immune disorder,making it a molecular target for prevention and treatment of major diseases.