食管癌组织MTA1蛋白表达与患者临床病理特征及3年生存率的关系

Relationship between MTA1 protein expression in esophageal cancer tissue with clinicopathological features and 3-year survival rate

目的探讨食管癌组织中肿瘤转移相关蛋白1(MTA1)的表达与临床病理特征、3年生存率的关系。方法选取2010年1月至2012年12月该院病理科收集的96例食管癌患者术后病理标本、符合纳入标准的癌旁组织标本40例采用免疫组织化学染色,分析MTA1蛋白表达与患者临床病理特征及远期生存率的关系。结果食管癌组织中MTA1蛋白阳性表达率(73.96%)显著高于癌旁组织的2.50%(P<0.05);食管癌组织中MTA1蛋白阳性表达主要与患者的TNM分期、淋巴结转移具有显著的相关性(P<0.05);食管癌组织中MTA1蛋白阳性表达患者的3年生存率(33.80%)显著低于阴性患者(60.00%)(P<0.05);食管癌患者的远期生存率与TNM分期、MTA1蛋白表达具有显著的关系(OR=1.638、1.433,P<0.05)。结论食管癌组织中MTA1蛋白高表达,并且与患者的TNM分期、淋巴结转移有关,MTA1蛋白高表达是食管癌患者预后的独立危险因素。

Objective To investigate the expression of tumor metastasis associated protein 1 （MTA1） in esophageal cancer tissue and its relationship with clinicopathological features and 3-year survival rate. Methods Ninety-six postoperative pathological samples of esophageal cancer and 40 samples of paracancerous tissue conforming to the inclusion standard collected by the patholog- ical department of this hospital from January 2010 to December 2012 were selected and performed the immunohistochemical stai- ning. Then the relationship between MTA1 protein expression with the clinicopathological features and long term survival rate was analyzed. Results The .MTA1 protein expression rate in the esophageal cancer tissues was 73.96 %,which was significantly higher than 2.50% in paracancerous tissues （P〈0.05） ;esophageal cancer tissues MTA1 protein expression mainly had significant corre- lation with TNM stage and lymph node metastasis（P〈0.05） ~the 3-year survival rate in the patients with esophageal cancer tissue MTA1 protein positive expression was 33.80%, which was significantly lower than 60.00% in the patients with MTA1 protein negative expression （P〈0.05）;the long-term survival rate in the patients with esophageal cancer had significant relationship with TNM staging and MTA1 protein expression （OR= 1. 638,OR= 1.43a, P〈0.05）. Conclusion MTA1 protein is highly expressed in esophageal cancer tissue,and has the relationship with TNM stage and lymph node metastasis, MTA1 protein high expression is an independent risk factor for the prognosis in the patients with esophageal cancer.