摘要
齐墩果酸连续灌胃给药5d,发现其对正常小鼠组织中PGE_2、PGF_(2α)的合成有显著刺激作用,能够诱导cAMP含量明显增加,cGMP含量明显下降,并对组胺释放有抑制作用。
Effects of oleanolic acid on immunoregulation were investigated in mice on the molecular level. Results showed that oleanolic acid could stimulate the biosynthesis or release of prostaglandins E2, F2α ( PGE2, PGF2α ) and cAMP, whereas had an inhibitory action on cGMP and histamine. Prostaglandins, cyclic nucleotides and histamine participate in many bodily functions, including regulation of blood pressure, immune function. It is suggested that their interaction may be of potential importance as a possible mechanism by which oleanolic acid acts in disease.
出处
《中国药理学通报》
CAS
CSCD
北大核心
1991年第3期179-181,共3页
Chinese Pharmacological Bulletin
关键词
齐墩果酸
PGE2
PGE2α
组胺
Oleanolic acid
Prostaglandin E_2
Prostaglandin F_2α
cAMP
cGMP
Histamine
