HPV感染与原发性肺癌预后的相关性分析

Association between human papillomavirus infection and prognosis of lung cancer

目的探讨人乳头瘤病毒(HPV)感染与原发性肺癌预后的相关性。方法检测83例肺癌组织中HPV感染情况,比较不同性别、年龄、吸烟、病理类型、肿瘤最大径、临床分期、淋巴结转移、远处转移、胸腔积液及化疗方式情况下,HPV阳性与阴性患者的生存差异。结果 83例肺癌组织中分别检出7例HPV阳性,HPV感染与性别、年龄、吸烟、病理类型、肿瘤最大径、临床分期、淋巴结转移、远处转移、胸腔积液及化疗方式无关(P>0.05)。分层分析结果显示,HPV阳性患者的生存期与阴性患者相比,差异均无统计学意义(P>0.05)。Cox多因素回归分析(包含HPV感染因素)显示结果类似,淋巴结转移为影响患者预后的独立危险因素[HR=11.078(95%CI:1.819~67.454)]。结论在福建肺癌人群中,未发现HPV感染与原发性肺癌预后有明显关联。

Objective To investigate the association between human papilomavirus （ HPV） andprognosis of lung cancer. Methods We examined a series of 83 lung cancer patients from the presence of HPV DNA in lung tumor specimens. The survival diferences of HPV positive and negative patients were compared between different sexes, ages, non-smoking and smoking, pathological types,maximal diameters of tumor,clinical stages,lymph node metastases,distant metastases,pleural and chemotherapy methods. Results HPV-positiveness was detected to be in 7 out of 83 tumorspecimens. There was no significant correlation found between HPV infection and the genders,ages,non-smoking and smoking, pathologic types,maximum tumor diameters, clinical stages,lymph node metastases,distant metastases,pleural effusions and chemotherapy methods（P 〉0？ 05）. Stratification analysis showed that when HPV positive patients were compared witli HPV the differences in their survival were not statistically significant （ P 〉 0. 05 ）. Cox multivariate regression analysis （including HPV infection） showed similar results,lymph node metastasis were independent riskfactors for prognosis [ HR = 11. 078 （95% CI： 0. 819-67.454 ） ]. Conclusion These data indicate thatHPV is not significantly associated witi the prognosis of lung cancer in Fujian.