中药传统汤剂与颗粒制剂对支气管哮喘热哮证临床疗效的对比研究

Comparative study on the clinical efficacy of traditional Chinese medicine decoction and granule preparation on bronchial asthma

目的观察疏风定喘汤不同剂型对支气管哮喘热哮证患者的临床疗效。方法选取2014年11月至2015年12月就诊于天津中医药大学第二附属医院呼吸科就诊的支气管哮喘热哮证患者41例。按服用剂型不同分为2组,其中中药汤剂组26例,中药颗粒制剂组15例。中药汤剂组予疏风定喘汤传统汤剂治疗,中药颗粒组予疏风定喘汤颗粒制剂治疗。治疗30 d后,观察2组治疗前后中医证候积分、哮喘控制测试(asthma control test,ACT)评分、肺功能指标的变化。结果疏风定喘汤传统汤剂、疏风定喘汤颗粒制剂治疗支气管哮喘热哮证均能有效控制哮喘症状,2组治疗后较同组治疗前中医证候积分明显降低,ACT评分提高,肺功能指标提高,差异有统计学意义(P<0.05)。2组间治疗后中医证候积分、ACT评分、肺功能指标比较差异无统计学意义(P>0.05)。结论疏风定喘汤传统汤剂与疏风定喘汤颗粒制剂治疗支气管哮喘热哮证疗效相当,颗粒制剂可替代汤剂应用于支气管哮喘热哮证的治疗。

Objective To observe therapeutic effects of Shufeng Dingchuan drug in different dosage forms on the patients with bronchial asthma. Methods Forty-one patients with bronchial asthma,who sought medical care in the Department of Respiration of the hospital from November 2014 to December 2015,were recruited for the study. The patients were divided into the traditional Chinese medicine decoction group（n = 26） and the granule preparation group（n = 15）. The patients of the traditional Chinese medicine decoction group were given Shufeng Dingchuan decoction,while the patients of the granule preparation group received Shufeng Dingchuan granules. After 30 days of treatment,changes in traditional Chinese medicine syndrome scores,asthma control test（ACT） scores and indicators of pulmonary function were observed and compared before and after treatment. Results Both Shufeng Dingchuan decoction and Shufeng Dingchuan granules could effectively control the symptoms of bronchial asthma. Following treatment,traditional Chinese medicine（TCM） syndrome scores were all decreased considerably,as compared with those before treatment in the same groups. ACT scores and pulmonary function scores were increased,and statistical significance could be found when comparisons were made between the same groups（P〈0. 05）. However,there was no statistical significance in TCM syndrome scores,ACT scores and pulmonary function scores,when comparisons were made between the 2 groups（P〈0. 05）. Conclusion In the treatment of bronchial asthma of heat type,Shufeng Dingchuan decoction and Shufeng Dingchuan granules could achieve identical therapeutic effects. For the sake of convenience,Shufeng Dingchuan granules could replace Shufeng Dingchuan decoction in the treatment of the disease.