阿立哌唑与氟哌啶醇治疗青少年精神分裂症的对照研究

Comparative study of Aripiprazole and Haloperidol in treatment of adolescent schizophrenia

目的:观察阿立哌唑与氟哌啶醇治疗青少年精神分裂症的疗效及安全性。方法:将80例青少年精神分裂症患者按简单随机抽样法分为研究组(阿立哌唑组)38例和对照组(氟哌啶醇组)42例,分别给予阿立哌唑和氟哌啶醇治疗,疗程8周。采用阳性和阴性综合征量表(PANSS)评定疗效,用不良反应量表(TESS)评定不良反应。结果:研究组疗效与对照组总疗效相似,无统计学差异(P>0.05),但研究组阴性症状改善较对照组明显,且不良反应也明显少于对照组(P<0.05)。结论:阿立哌唑治疗青少年精神分裂症安全有效,不良反应少,患者依从性好,服药方便,更适合青少年使用。

Objective：To observe efficacy and safety of Aripiprazole and Haloperidol in treatment of adolescent schizophrenia.Methods：80 adolescent schizophrenics were randomly divided into two groups according to the simple random sampling method：Aripiprazole group（n=38）and Haloperidol group（n=42）.The course of treatment was 8 weeks.The positive and negative symptom scale（PANSS）was used to evaluate the effects,and the adverse reactions were evaluated by the treatment emergent symptom scale（TESS）.Results：The efficacy of Aripiprazole group is similar to that of Haloperidol group,and there was no significant difference（P〈0.05）.The improvement of the negative symptoms in Aripiprazole group was significantly higher than that in Haloperidol group,and the adverse reactions were less in Aripiprazole group than in Haloperidol group（P〈0.05）.Conclusions：Aripiprazole in the treatment of adolescent schizophrenia is safe and effective,has less adverse reactions and good compliance,is easy to take,and is more suitable for the adolescents.