血清IFN-γ、OPN、IL-18检测对肺结核患者的临床意义

Clinical significance of combined detection of serum IFN-γ,OPN and IL-18 in patients with pulmonary tuberculosis

目的探讨血清干扰素(IFN)-γ、骨桥蛋白(OPN)、白细胞介素(IL)-18检测对肺结核患者的临床意义。方法选取2013年9月至2016年11月该院门诊收治的55例肺结核患者作为肺结核组,选取同期健康体检者60例作为对照组。比较肺结核组和对照组、痰涂片抗酸杆菌阳性和阴性患者、其他不同病理分组血清IFN-γ、OPN和IL-18水平。结果肺结核组的IFN-γ、OPN和IL-18水平明显高于对照组,差异有统计学意义(P<0.05)。痰涂片抗酸杆菌阳性患者IFN-γ、OPN和IL-18水平明显高于阴性患者,差异有统计学意义(P<0.05)。粟粒性肺结核患者IFN-γ、OPN和IL-18水平明显高于空洞性肺结核、结核性胸膜炎及浸润性肺结核患者,而空洞性肺结核患者IFN-γ、OPN和IL-18水平明显高于结核性胸膜炎及浸润性肺结核患者,差异有统计学意义(P<0.05)。结论肺结核患者IFN-γ、OPN、IL-18水平较高,3项指标可作为评估肺结核病情进展及严重程度的敏感指标。

Objective To investigate the clinical significance of combined detection of serum IFN-γ,OPN and IL-18 in patients with pulmonary tuberculosis.Methods From September 2013 to November 2016,55 patients with pulmonary tuberculosis in the hospital were selected as the tuberculosis group,at the same time,60 healthy persons were selected as control group.The levels of IFN-γ,OPN and IL-18 in serum of patients with pulmonary tuberculosis and control group,sputum positive and negative pulmonary tuberculosis and different pathological groups were compared.Results The levels of IFN-γ,OPN and IL-18 in tuberculosis group were higher than those in control group,the difference was statistically significant（P〈0.05）.The levels of IFN-γ,OPN and IL-18 in serum of sputum positive pulmonary tuberculosis patients were higher than those of sputum negative pulmonary tuberculosis patients,the difference was statistically significant（P〈0.05）.Serum IFN-γ,OPN and IL-18 of miliary tuberculosis patients were higher than that of cavitary pulmonary,tuberculous pleurisy and invasive,the cavitary pulmonary tuberculosis in patients with IFN-γ,OPN and IL-18 were higher than that of tuberculous pleurisy and invasive,the differences were statistically significant（P〈0.05）.Conclusion The levels of serum IFN-γ,OPN and IL-18 in patients with pulmonary tuberculosis are high,which can be used as a sensitive index to evaluate the progress and severity of pulmonary tuberculosis.