乳腺癌雌激素受体水平与MRI影像学表现的相关性研究

Correlation study of estrogen receptor and MRI morphological features for breast cancer

介绍了乳腺癌雌激素受体(estrogen receptor,ER)表达状况与MRI表现如针刺样边缘、环形强化、时间-信号曲线(time-to-intensity curve,TIC)类型及表观扩散系数(analog-to-digital converter,ADC)间的关系,提出了不同ER表达状况的患者MRI特征性表现不同,其最主要的原因可能是ER表达阳性抑制新血管生成,通过影响病灶的纤维化及坏死程度、生长速度、灌注情况等,引起MRI形态学、强化形态、强化方式及弥散方面的差异。指出可以通过MRI动态增强的形态学表现及弥散加权成像的ADC值评估患者的激素水平,从而为临床精准评估乳腺癌预后及尽早制定诊疗方案提供更有价值的信息,亦为以后ER表达状况与TIC曲线类型的相关性研究提供指导。

The expression status of estrogen receptor(ER) and MRI features of breast cancer were introduced, which included needle-like edge, ring enhancement, types of time-to-intensity curve(TIC) as well as the relationship between ADC values. The breast cancer patients with expression statuses had different MRI features including MRI morphology,enhancement state, enhancement mode and diffusion, and the main cause was that ER positive expression suppressed neovascularization to influence the focal fibrosis, necrosis, growth rate, perfusion and etc. Hormone level was pointed out to be evaluated by morphological manifestations of MRI dynamic enhancement and ADC value of diffusion weighted imaging, so that valuable information could be provided for the prognosis evaluation, treatment planning as well as the studies on ER expression status and TIC types.