结节性硬化症患者皮质结节的MRI表现及表观扩散系数值特征分析

MRI finding and ADC measurements of cortical tubers in patients with tuberous sclerosis complex

目的观察结节性硬化症(tuberous sclerosis complex,TSC)患者大脑皮质结节的MRI表现及表观扩散系数(apparent diffusion coefficient,ADC)值的特征。方法回顾性分析21例TSC患者的颅脑MRI表现,根据皮质结节MRI表现特点,将其分为典型皮质结节组及囊性皮质结节组,记录各组皮质结节的结节数量并测量皮质结节的ADC值。结果 21例患者均有皮质结节,其中典型皮质结节组9例,囊性皮质结节组12例。室管膜下结节MRI表现为T1WI序列呈等或稍高信号,T2WI序列呈稍低信号小结节状影。囊性皮质结节组患者的皮质结节平均数量多于典型皮质结节组(P<0.05),2组室管膜下结节的平均数量差异无统计学意义(P>0.05)。囊性皮质结节组结节的平均ADC值高于典型皮质结节组(P<0.05)。结论 TSC患者皮质结节的MRI表现分为典型皮质结节及囊性皮质结节,囊性皮质结节组结节数量多于典型皮质结节组,囊性皮质结节的ADC值高于典型皮质结节。

Objective To analyze MRI features and ADC values of cortical tubes in patients with tuberous sclerosis complex(TSC).Methods The MR images of 21 patients with TSC were reviewded retrospectively,typical and cyst-like cortical tubers types were identified based on the MRI signal intensity of cortical tube,all patients were divided into two groups corresponding to the tube type.The cortical tube counts were recorded.ADC values of cortical tube were measured.Results Of 21 patients with TSC,the group of typical cortical tuber was 9 cases,another group was 12 cases. Subependymal nodule appears as isointensity or hyperintensity on T1-weighted images and hypointensity on T2-weighted images.Mean cortical tuber count in cyst-like cortical tuber group was more than the count in typical cortical tuber group(P<0.05).There was no significant difference in the average number of subependymal nodules between the 2 groups(P>0.05).Mean ADC value of cyst-like cortical tuber group was higher than the value of typical cortical tuber group(P<0.05).Conclusion Typical cortical tubers and cyst-like cortical tubers were identified,mean tuber count in cyst-like cortical group was more than that in typical cortical tubers group,ADC values of cyst-like cortical tuber was higher than that in typical cortical tuber.