基于酸甘化阴理论乌梅喷雾剂改善血液透析患者口渴症的效果观察

Influence of Dark Plum Aerosol on Hemodialysis Patients with Xerostomia Based on Theory of Sour-sweet Herbs Nourishing Yin

目的基于酸甘化阴理论,探讨乌梅喷雾剂改善维持性血液透析患者口渴症状的有效性。方法采用随机对照试验,选取血液透析室有口渴症的维持性血液透析患者60例,通过信封法随机分为干预组和对照组,各30例。干预组在常规治疗与护理的基础上给予乌梅喷雾剂喷雾,对照组在常规治疗与护理的基础上温开水喷雾,收集并比较2组受试者口渴程度评分、唾液静息流率。结果干预前,干预组及对照组的基线资料及口渴强度比较无统计学意义(P>0.05)。干预后,口渴程度评分显示干预组(21.8±1.5)分较对照组(28.7±1.8)分更能有效地降低患者口渴程度(P<0.01)。干预组和对照组2 min静态唾液流率分别为(1.0±0.5)mg/min和(0.3±0.1)mg/min。结论乌梅喷雾剂可有效缓解维持性血液透析患者口渴症状,提高患者唾液静息流率,较少患者的液体摄入量,从而减轻心血管的负担,对于透析患者健康状况具有积极的临床意义。

Objective To explore the effect of dark plum aerosol on alleviating thirsty in uremic patients with hemodialysis based on the theory of sour-sweet herbs nourishing Yin. Methods We conducted a randomized controlled trial. Sixty hemodialysis patients with xerostomia were divided into intervention group（n=30） and control group（n=30）. The intervention group was given conventional nursing and dark plum aerosol while control group received conventional nursing and warm water aerosol. Thirsty grades and resting salivary flow rates were compared between 2 groups. Results Before the intervention, the difference of baseline data and thirsty degree between 2 groups was not statistically significant（P〉0.05）. After the intervention, Thirsty degree score of intervention group and control group were respectively 21.8 ±1.5 and 28.7 ±1.8, thirsty degree score of intervention group decreased obviously when compared with that of control group（P 〈0.01）. The 2 min resting salivary flow rates of intervention group and control group were respectively 1.0±0.5 mg/min and 0.3±0.1 mg/min and it had a statistical significance（P〈0.01）. Conclusion Dark Plum Aerosol can effectively reduce the degree of thirsty and increase resting salivary flow rates. Thus, it can reduce fluid intake and the burden of cardiovascular in hemodialysis patients thus it can be promoted clinically.