微流控芯片中颗粒/细胞磁操控的研究进展

Advances of Particles/Cells Magnetic Manipulation in Microfluidic Chips

微流控芯片中颗粒/细胞的磁操控是当前的热点研究领域。本文详细介绍了微流控芯片中颗粒/细胞磁操控原理及几种主要操控方式,包括分离、集中、捕获与排列组装。其中,基于颗粒/细胞大小、形状以及有无磁性对分离方法展开详述。此外,本文还比较了通道几何结构、磁场强度及分布、磁性液体种类(顺磁盐溶液和磁流体)对操控性能的影响。最后,针对微流控芯片中颗粒/细胞磁操控的前景进行了展望。

Magnetic manipulation of particles cells in microfluidic chips is a promising research field. This paper stated the operation mechanism and the main means of manipulation, including separation, concentration, capture, arrangement and assembly. Especially, the concept of particles/cells separation was emphasized with different criteria, like sizes, shapes, and magnetic properties. In addition, the effects of the channel geometry, the intensity and distribution of the magnetic field, and the types of magnetic liquid （paramagnetic salt solutions and ferrofluids） on the performance of the magnetic manipulation were also compared. The prospective to the prospect of magnetic manipulation about particles/cells in microfluidic chip was also depicted.