远隔肢体缺血后适应对急性脑梗死病人血清肿瘤坏死因子-α的影响

Effects of Post-ischemic Postconditioning on TNF-αin Patients with Acute Cerebral Infarction

目的探讨远隔肢体缺血后适应对急性脑梗死病人血清肿瘤坏死因子-α(TNF-α)的影响。方法选择2013年3月—2014年12月于我院接受治疗的286例急性脑梗死病人,按接受治疗时间分为72h内就诊的观察组与对照组,72h后至1周内就诊的观察组与对照组,比较4组病人神经功能(NIHSS)评分情况、TNF-α水平变化情况。结果治疗后72h内就诊的观察组病人NIHSS评分明显优于对照组;72h后至1周内就诊的观察组病人NIHSS评分优于对照组。而72h内就诊的观察组病人NIHSS评分则优于72h后至1周内就诊的观察组病人,差异有统计学意义(P<0.05)。将不同治疗时间观察组和对照组合并后,比较TNF-α水平变化,观察组病人TNF-α水平低于对照组,差异有统计学意义(P<0.05)。结论远隔肢体缺血后适应可有效降低急性脑梗死病人TNF-α水平,通过此机制可起到神经保护的作用。

Objeciive To investigate the effect of post ischemic postconditioning on tumor necrosis factor α （TNF-α） in patients with acute cerebral infarction （ACI） .Meihods Two hundreds and eighty six patients with ACI from March 2013 to December 2014 in our hospital were divided into 72 hours observation group and the control group, 72 hours to 1 week after treatment of the observation group and the control group.The National Institute of Health Stroke Scale （NIHSS） scores？and TN-α levels were observed.Results After treatment of 72 hours, the NIHSS scores in observation group within 72 hours were better than that in control group.The NIHSS scores in observation group were superior to that of the control group after 72 hours to 1 week（ P 〈0.05）. The level of TNF a in observation group was lower than that in control group （ P 〈0.05） .Conclusion Ischemic posterior limb adaptation can effectively reduce the blood levels of TNF a in patients with ACI.