胺碘酮治疗老年心律失常疗效与安全性分析

Analysis on Effect and Safety of Samiodarone in the Treatment of Arrhythmia in the Aged

目的:对胺碘酮治疗老年心律失常的临床疗效与安全性进行探究。方法:以纳入标准、排除标准为依据,选取我院2014年5月至2016年5月内已签署知情同意书且符合胺碘酮适应证(心房颤动、室性心律失常)的120例年龄≥60岁且≤89岁的老年心律失常患者为研究对象,依照患者住院号奇偶数分为对照组(60例)和观察组(60例),对照组接受利尿、强心、扩血管等常规综合治疗,在对照组基础上观察组加以口服胺碘酮治疗,经相关临床诊断证实所有患者均符合胺碘酮适应证,并展开此研究,分析两组临床疗效、不良反应情况。结果:观察组心律失常总有效率为(93.33%),对照组心律失常总有效率为(76.67%),组间差异具有显著性(χ2=6.536,P<0.05);观察组心功能改善总有效率为(91.66%),对照组心功能改善总有效率为(75.00%),组间差异具有显著性(χ2=6.000,P<0.05);观察组心律次数较对照组明显降低,差异具有统计学意义(P<0.05);观察组不良反应率低于对照组,差异具有统计学意义(χ2=5.175,P<0.05)。结论:心律失常老年患者在接受常规综合治疗基础上加以胺碘酮,临床疗效显著,安全可靠,值得应用。

Objective： To explore the clinical effect and safety of amiodarone in the treatment of arrhythmia in the aged. Methods： 90 elderly patients with arrhythmia treated in this hospital from May 2014 to May 2016 were selected as the research objects and they were divided into the control group （45 cases） and observation group （45 cases） according to the odd and even hospital numbers. Patients in the control group were given the clinical routine comprehensive treatment, while patients in the observation group were given the oral administration of amiodarone based on the routine treatment. The clinical effect and adverse reactions were analyzed. Results： After the treatment, the overall response rate of arrhythmia for patients in the observation group was significantly higher than that in the control group, with the statistical difference （p〈0.05）; the overall response rate of cardiac function for patients in the observation group was significantly higher than that in the control group, with the statistical difference （p〈0.05）; the indicators of heart rate and QT interval prolongation for patients in the observation group were significantly better than that in the control group, with the statistical difference （p〈0.05）; and the rate of adverse reactions for patients in the observation group was lower than that in the control group, with the statistical difference （p〈0.05）. Conclusion： The oral administration of amiodarone for the elderly patients with arrhythmia based on the routine treatment has the obvious clinical effect with the high safety and effectiveness.