摘要
目的探讨五酯片治疗轻度药物性肝损伤的临床疗效。方法择2016年1~12月在我院诊断为药物性肝损伤的患者100例为研究对象,随机分为研究组与对照组各50例。研究组采用五酯片治疗,对照组给予甘草酸二铵肠溶胶囊治疗。治疗14 d观察临床疗效。结果两组总有效率比较,差异无统计学意义(P>0.05);但研究组显效率显著高于对照组,差异有统计学意义(P<0.05)。治疗前两组ALT、ALP及TB水平均显著升高,组间比较差异无统计学意义(P>0.05);治疗14 d后,两组ALT、ALP及TB水平均显著下降,与治疗前比较,差异有统计学意义(P<0.05);治疗后,研究组ALT、ALP以及TB水平显著低于对照组,差异有统计学意义(P<0.05)。结论五酯片治疗轻度药物性肝损伤具有较好的临床疗效。
Objective To evaluate the clinical efficacy of Wuzhi tablets in the treatment of mild drug-induced liver injury. Methods A total of 100 patients who were diagnosed as drug-induced liver injury in our hospital from January to December 2016 were selected as the study subjects, and they were randomly divided into study group and control group(n=50). The study group was given Wuzhi tablets, and the control group was given diammonium glycyrrhizinate enteric-coated capsules. The treatment lasted for 14 days to observe the clinical efficacy. Results There was no statistically significant difference in the total effective rate between the two groups(P〈0.05); but the significantly effective rate in the study group was significantly higher than that in the control group, and the difference was statistically significant(P〈0.05). The levels of ALT, ALP and TB were significantly increased in the two groups before treatment, and there was no statistically significant difference between the two groups(P〈0.05); after 14 days of treatment, the levels of ALT,ALP and TB were significantly decreased in both groups. Compared with that before treatment, the difference was statistically significant(P〈0.05); after treatment, the levels of ALT, ALP and TB in the study group were significantly lower than those in the control group, and the difference was statistically significant(P〈0.05). Conclusion There is a good clinical effect of Wuzhi tablets in the treatment of mild drug-induced liver injury.
出处
《中国现代医生》
2017年第28期85-87,共3页
China Modern Doctor
关键词
五酯片
轻度
药物性
肝损伤
Wuzhi tablets
Mild
Drug-induced
Liver injury