成年妇女体重增加速度与多囊卵巢综合征发病关系的研究

Relationship between incidence of polycystic ovary syndrome and weight gain rate in adult women

目的研究多囊卵巢综合征(PCOS)成年患者发病和体重增加速度的关系。方法 2011年11月到2017年2月,采用病例对照研究,将就诊前3个月内新发的PCOS妇女218人纳入病例组,同期就诊的有规律月经和排卵的妇女268人纳入对照组,回顾性收集研究对象1年内的体重变化,并对病例组妇女实施胰岛素释放和糖耐量实验。结果病例组患者的年体重增加比显著高于对照组(4.550%vs.1.420%,P<0.05)。非肥胖的研究对象中,病例组的年体重增加比仍显著高于对照组(2.492%vs.1.386%,P<0.05)。在病例组对象中,空腹血糖和胰岛素异常的发生率显著高于1年前(47.5%vs.18.3%,P<0.05),且总体糖代谢和胰岛素分泌异常的异常程度和年体重增加比呈正相关(Rs=0.207,P<0.05)。结论妇女PCOS发病可能与体重增加速度有关。

Objective： To study the relationship between the incidence of polycystic ovary syndrome（PCOS）and weight gain rate in adult women.Methods： A total of 218 women who suffered menstrual disorder in recent 3 months and were diagnosed as PCOS（case group）and 268 women with regular ovulation（control group）were enrolled in this study from Nov,2011 to Feb,2017.The information including weight gain within the past one year was retrospectively collected.The women in case group were administered the test of insulin release and glucose tolerance.Results： The annual weight gain rate in case group was significantly higher than that in control group（4.550% vs.1.420%,P〈0.05）.Among the non-obese women,annual weight gain rate in case group was also significantly higher than that in control group（2.492% vs.1.386%,P〈0.05）.Abnormality rate of fasting blood glucose（FG）and fasting insulin（FIN）was significantly higher than one year ago in case group（47.5% vs.18.3%,P〈0.05）.The abnormal degree of glucose metabolism and insulin secretion was positively related with annual weight gain rate（Rs=0.207,P〈0.05）.Conclusions： The incidence of PCOS in women may be related to weight gain rate.