摘要
报道了一种过渡金属钯催化的由取代吲哚与苯丙酮类化合物直接脱氢偶联构筑咔唑衍生物的新方法.反应经历饱和苯丙酮类化合物的原位脱氢形成烯烃中间体,该中间体直接与吲哚发生反应脱氢环化,省略了底物的预活化,为咔唑衍生物的合成提供原子和步骤经济的合成路径.
The synthesis of carbazoles via Pd-catalyzed direct cross-coupling of indoles with in situ generated aryl vinyl ketones by using statured ketones as the olefins source is described. This protocol obviates the need for additional preparation steps of aryl vinyl ketones and therefore opens up a new door to synthesis of carbazoles in an atom-and step-economical fashion.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2017年第10期2655-2662,共8页
Chinese Journal of Organic Chemistry
基金
Project supported by the National Natural Science Foundation of China(Nos.21431008,21332001,21602221,u1505242)~~
关键词
钯催化
脱氢
咔唑
C—H键官能团化
交叉偶联
palladium-catalyzed
dehydrogenation
carbazoles
C—H functionalization
cross-coupling
