荞麦地鼠尾草根中的二萜类成分

Diterpenes from the Roots of Salvia kiaometiensis Lévl

对民间丹参代用品荞麦地丹参(Salvia kiaometiensis Lévl.)乙醇提取物进行化学成分研究,通过现代多种色谱技术和波谱技术,从中分离并鉴定16个二萜类化合物,分别是6,8,11,13-abietatetraen-12-ol dimer(1),kiaometin(2),miltirone(3),tanshinone IIA(4),crypotanshione(5),tanshindiol C(6),ferruginol(7),2-isopropyl-8-methylphenanthrene-3,4-dione(8),tanshinone I(9),trijuganone B(10),dihydrotanshinone I(11),grandifolias C(12),przewalskin(13),tanshinlactone(14),6,7,8,9-tetrahydro-1,6,6-trimethylfuro[3,2-c]naphtha[2,1-e]oxepine-10,12-dione(15),almilalbanone(16).其中,化合物1为新的松香烷型二萜的二聚体,2为新的降松香烷型二萜化合物,其B环7,8位开环后又通过醚桥连接起来.所有化合物均为首次从该种植物中得到.

Through a variety of chromatographic techniques and spectroscopic methods, sixteen diterpenes were isolated and identified from the ethanol extraction of the roots of Salvia kiaometiensis Lévl. Their structures were identified to be 6,8,11,13-abietatetraen-12-ol dimer （1）, kiaometin （2）, miltirone （3）, tanshinone ⅡA （4）, crypotanshione （5）, tanshindiol C （6）, ferruginol （7）, 2-isopropyl-8-methylphenanthrene-3,4-dione （8）, tanshinone I （9）, trijuganone B （10）, dihydrotanshinone I （11）, grandifolias C （12）, przewalskin （13）, tanshinlactone （14）, 6,7,8,9-tetrahydro-1,6,6-trimethylfuro[3,2-c]naphtha[2,1-e]oxepine-10,12-dione （15）, and salmilalbanone （16）. Compound 1 is a new abietane diterpenes dimer, and compound 2 is a new 7,8：7,20-diepoxy-nor-abietane diterpenes. All of the diterpenes were isolated from this plant for the first time.