无症状性颈动脉狭窄患者临床指标分析

Clinical indicators analysis of serum in symptomless carotid artery narrow patients

目的研究无症状性颈动脉狭窄患者血脂、血超氧化物歧化酶(SOD)、丙二醛(MDA)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平的变化。方法选择经彩色多普勒血流成像确诊的160例无症状性颈动脉狭窄的患者,分为4组,每组40例;另选40例无颈动脉狭窄的健康者为对照组。检测入组者的血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)以及血氧化修饰低密度脂蛋白、SOD、MDA、IL-6、TNF-α。结果与对照组比较,各狭窄组的TG、TC、LDL、MDA、IL-6、TNF-α水平均有明显升高(P<0.05),SOD活性和HDL水平显著降低(P<0.05);重度狭窄组、闭塞组以上指标的异常变化比中度狭窄组明显(P<0.05)。结论无症状性颈动脉狭窄患者存在血脂异常、抗氧化能力降低及炎性细胞因子增多,且随狭窄程度加重而更加明显,为该类患者临床防治用药提供了客观依据。

Objective To investigate into the blood lipid and superoxide dismutase（SOD）,malonaldhyde（MAD）,interleukin-6（IL-6） and tumor necrosis factor-α（TNF-α） of serum in symptomless carotid artery narrow patients.Methods Diagnoses of 160 cases of symptomless carotid artery narrowness after the colored Doppler supersonic diagnostic equipment narrowness and,then,according to the degree of carotid artery narrowness the cases were divided into 4 groups,with 40 were in the normal control group.The levels of blood lipid： total cholesterol（TC）; triglycerides（TG）; low density lipoprotein（LDL）; high density lipoprotein HDL）,and oxidized low density lipoprotein and SOD,MDA,IL-6 and TNF-α in each group were detected.Results Compared with normal control group the levels of TC,TG,LDL,MDA,IL-6,TNF-α significantly increased（both P〈 0.05） and HDL and SOD significantly decreased（ both P〈 0.05） in each narrow group; the abnormal changes of these indices in the severe group and block group were more obvious than in the moderate group（both P〈 0.05）.Conclusion The blood lipid is abnormal and the effect of antioxidation is lower and inflammatory factors are more in the symptomless carotid artery narrowness patients.