钙代谢调控机制研究进展

Research progress in regulation of calcium metabolism

钙代谢包括两种情况:钙平衡和钙稳态。钙平衡是指体内钙储存状态稳定,主要是指骨钙池的状态。钙稳态是指细胞内液和细胞外液的离子钙水平稳定。钙平衡和钙稳态的维持主要依赖3个器官:肠道、肾脏和骨,这3个器官在体内钙调控因子的作用下,维持钙平衡和钙稳态。体内主要的钙调控因子包括:甲状旁腺激素、1,25-羟维生素D3、降钙素和离子钙本身。本文就体内钙平衡和钙稳态的调控作一综述。

The two types of calcium metabolism are calcium balance and calcium homeostasis.Calcium balance is the storage of calcium in the body,referring mainly to the bone calcium pool.Calcium homeostasis is the stable level of calcium in intracellular and extracellular fluids.The regulation of calcium balance and homeostasis main depends on three organs： intestine,kidney and bone.These organs are under the regulation of calcium for hormones including parathyroid hormone,1,25-hydroxyvitamin-D,calcitonin and the ion calcium itself.This article reviewed the regulation of calcium balance and homeostasis.