骨科金属植入物表面载药抗菌涂层的研究进展

Research progress of drug-loaded antibacterial coating of orthopedic metal implants

目的总结近年来骨科金属植入物表面载药抗菌涂层的研究进展。方法检索查阅近年来国内外关于骨科金属植入物表面载药抗菌涂层的相关研究报道,对研究现状、分类及发展趋势进行总结。结果骨科金属植入物表面载药抗菌涂层在药物释放方式上可分为被动释放型和主动释放型。被动释放型载药涂层在植入体内后,无论植入物周围有无细菌都会持续被动地释放药物;而主动释放型载药涂层在植入物周围无感染时不释放或少量释放所搭载的药物,仅当其周围出现感染时,主动释放搭载药物,实现智能抗菌。结论药物的持续稳定释放是各种抗菌涂层需解决的关键问题,能够对细菌响应性释放载药的智能型抗菌涂层是今后载药抗菌涂层的发展方向。

Objective To investigate the research progress of drug-loaded antibacterial coating of orthopedic metal implants in recent years. Methods The recent literature on the drug-loaded antibacterial coating of orthopedic metal implants were reviewed. The research status, classification, and development trend of drug-loaded antibacterial coating were summarized. Results The drug-loaded antibacterial coating of orthopedic metal implants can be divided into passive release type and active release type according to the mode of drug release. Passive drug release coating can release the drug continuously regardless of whether the presence of bacteria around the implants. Active drug release coating do not release the drug unless the presence of bacteria around the implants. Conclusion The sustained and stable release of drugs is a key problem to be solved in various antibacterial coatings research. The intelligent antibacterial coating which release antibiotics only in the presence of bacteria is the future direction of development.