牛磺酸对大鼠心肌Ca^(2+)调节作用的研究

EFFECT OF TAURINE ON MODULATING CALCIUM OF CARDIAC MUSCLES IN RATS

研究了牛磺酸对大鼠离体左心室肌^(45)Ca内流的影响。对照组^(45)Ca内流与KH液中Ca_-^(2+)浓度有关。当Ca^(2+)浓度分别为0.62(低Ca^(2+)),1.25(正常Ca_-^(2+))和1.87(高Ca_-^(2+))mmol/L时,^(45)Ca内流相应为1.02±0.25,1.37±0.14,和1.45±0.14μmol/g。加入牛磺酸后,上述情况显著改变。低Ca_-^(2+),Tau 10、20、40mmol/L能分别使^(45)Ca内流增加为1.11±0.11,1.45±0.12和1.48±0.09μmol/g:正常Ca^(2+)时,Tau 10、20、40mmol/L能分别使^(45)Ca内流减少为1.19±0.07,1.14±0.23和0.97±0.24μmol/g:高Ca^(2+)时、Tau 10、20、40mmol/L能使^(45)Ca内流显著降低为1.12±0.05,0.58±0.18和0.53±0.10μmol/g。结果表明不同Ca^(2+)浓度能影响心肌^(45)Ca内流,牛磺酸对心肌^(45)Ca内流有双向调节作用,这可能在其抗心律失常机制中起重要作用。

The effect of Taurine ( Tau)on 45Ca influx of isolated left ventricular muscles in rats has been investigated. The 45Ca influx of the preparations untreated with Tau, are affected by the concentrations of calcium in KH solution. when the concentration of calcium is 0.62; 1.25; and 1.87mmol/L respectively, the 45Ca influx is 1.02± 0.25; 1.37±0.14 and 1.45±0.14 μmol/g wet tissue, respectively. After adding Tau, the situations above were changed significantly. It was shown that is 1.11 ± 0.11, 1.45±0.12, and 1.48 ± 0.09 μmol/g wet tissue in low Ca2±; 1.19±0.07, 1.14 ± 0.23, and 0.97±0.24 μmol/g wet tissue in normal Ca2±; and 1.12±0.05,0.58±0.18 and 0.53±0.10 μmol/g wet tissue in high Ca2± treated with Tau 10, 20, and 40 mmol/L, respectively. The results show that the varied ,Ca2± concentrations in KH solution can affect 45Ca influx of cardiac muscles, but Taurine has a bisphasic modulation o,f calcium influx in the same tissue. The effects of modulating calcium may play an important role for anti-arrhythmic mechanism of Taurine.