热带地区痛风与类风湿性关节炎患者生化指标比较

Differences in biochemical indicators between gout and rheumatoid arthritis patients in tropical areas: a comparative analysis

目的比较热带地区痛风及类风湿性关节炎患者的生化指标差异。方法 2014年1月—2016年12月间在某院住院治疗的海南痛风患者816例及类风湿性关节炎患者316例,对其部分生化指标进行比较分析,利用统计学软件SPSS19.0对组间数据进行分析。结果两组患者鳞状上皮细胞、非鳞状上皮细胞、尿粘液、尿蛋白、尿液酸碱度、血清尿酸、钙、钾、磷、氯、钠都存在组间统计学差异(P<0.05)。其中痛风组中尿蛋白的检出率为43.1%,为类风湿性关节炎组的检出率(23.4%)的1.84倍。尿酸在男性痛风组中的浓度为(446±141.1)μmol/L,在男性风湿性关节炎患者中的浓度为(315.44±156.55)μmol/L;在女性痛风患者中的浓度为(382.7±123)μmol/L,在女性类风湿性关节炎患者中为(223±94.7)μmol/L;钙浓度在痛风组和风湿组中分别为(2.03±0.19)mmol/L和(1.99±0.18)mmol/L,差异有统计学意义(P<0.01)。结论临床生化指标差异不能作为2种病症的鉴别诊断依据。

Objective To compare differences in biochemical indicators between the patients with gout and rheumatoid arthritis in tropical areas. Methods We extracted data on biochemical indicators from medical records of 316 gout patients and 816 rheumatoid arthritis patients hospitalized in a hospital in Hainan province from January 2014 through December 2016. SPSS19.0 was adopted to analyze detection results of the indicators of the two group patients. Results There were significant differences in urinary squamous cell count, urinary non squamous epithelial cell count, urinary mu- cus, urinary protein, urine pH value, serum uric acid, calcium, potassium, phosphorus, chlorine, and sodium between the two groups （ P 〈0. 05 for all）. The positive rate of urinary protein in the gout patients was 43.1% ,which was 1.84 times higher than that （23.4%） of rheumatoid arthritis patients. The mean concentration of serum uric acid was 446 ± 141.1 μmoL/L and 315.44 ± 156. 55 μmoL/L in male gout and rheumatoid arthritis patients;while in female gout and rheumatoid artlu＇itisis patients ,the concentration was 382. 7 ± 123 μmol/L and 223 ±94. 7 μmol/L. The concentration of serum calcium was 2. 03 ± 0. 19 mlnol/L and 1.99±0. 18 mmol/L in the gout and rheumatoid arthritis patients,with a significant difference （P 〈 0.05）. Condusion The difference in clinical biochemical indexes between gout and rheumatoid arthritis patients can not be used as a basis for the differentiation diagnosis of gout and rheumatoid arthritis. Key words ： gout; rheumatoid arthritis ; clinical index