ω-3多不饱和脂肪酸治疗56例新生儿感染性肺炎临床疗效观察

Curative Effect of ω-3 Polyunsaturated Fatty Acids on 56 Neonatus with Infectious Pneumonia

目的:探讨ω-3多不饱和脂肪酸对新生儿感染性肺炎的临床疗效及安全性。方法:选取2014年5月至2017年1月我院收治的56例新生儿感染性肺炎患者作为研究对象,按其治疗方法将其分为对照组和观察组,每组28例,对照组患儿予以感染性肺炎常规对症治疗,观察组患儿在对照组治疗基础上予以ω-3多不饱和脂肪酸治疗,治疗结束后比较2组患儿其相关临床症状消失时间、相关临床指标水平及临床疗效,并记录2组患儿治疗过程中其不良反应的发生情况。结果:(1)2组患儿治疗后其TNF-α、IL-6和CRP水平均较治疗前有所降低,并且观察组降低程度均明显大于对照组(P<0.05);(2)观察组患儿其临床症状消失时间及住院时间均明显低于对照组(P<0.05);(3)观察组患儿其临床总有效率(92.86%)明显高于对照组(69.23%)(P<0.05);(4)2组患儿不良反应比较(10.71%VS 7.14%)无差异(P>0.05),且无其他严重不良反应的发生。结论:ω-3多不饱和脂肪酸对治疗新生儿感染性肺炎具有显著的临床疗效和一定的安全性。

Objective： To investigate the curative effect and safety of ω-3 polyunsaturated fatty acids on 56 neonatus with infectious pneumonia. Methods： 56 neonatus with infectious pneumonia from May 2014 to January 2017 in our hospital were divided into the control group and the experimental group according to treatment, 28 cases in each group. The control group was given conventional treatment of infectious pneumonia, the observation group was treated with Omega -3 polyunsaturated fatty acids on the basis of the control group. After treatment, compared the differences of clinical symptom disappearance time, clinical index level, clinical efficacy between two groups. Results： （1） After treatment, the TNF- α, IL-6 and CRP levels of two groups were lower than before treatment, and the observation group was significantly lower than the control group （P〈0.05）; （2） The clinical symptoms disappeared time and hospitalization time of the observation group were significantly lower than those in the control group （P〈0.05）; （3） The total effective rate of the observation group （92.86%） was significantly higher than 69.23% of the control group （P〈0.05）;（4） There was no significant differ- ence in adverse reactions （10.71% VS 7.14%） between the two groups （P〉0.05）, and no other serious adverse events occurred. Conelusion： ω -3 polyunsaturated fatty acids has a good curative effect and safety on neonatus with infectious pneumonia.