运动干预对老年MCI患者认知功能及血清IGF-1水平的影响

Exercise Intervention on Elderly Cognitive Function in Patients with MCI and the Influence of the Level of Serum IGF-1

目的:探讨运动干预对老年MCI患者认知能力以及IGF-1水平的影响,以及IGF-1水平变化与认知功能改善的相关性。方法:选取苏州市立医院下属润达社区89例老年MCI患者参与本次探究,将其按照随机数字表法分为干预组与对照组,对干预组进行18个月的运动干预,并在6个月、12个月、18个月时分别进行认知能力评估及血清IGF-1水平测定。结果:干预组患者认知能力与IGF-1水平显著提高,且均有统计学意义(P<0.05)。结论:18个月的运动干预明显提升了老年MCI患者的血清IGF-1水平以及认知能力,并且显示血清IGF-1水平可能可以作为对MCI患者干预效果的标志物。

Objective： To explore the effect of exercise intervention on cognitive ability and IGF-1 level in elderly patients with MCI, and the correlation between the level of IGF-1 and the improvement of cognitive function. Methods： Suzhou Municipal Hospital affiliated harvesta community 89 elderly patients with MCI were involved in this study, they were randomly divided into intervention group and control group, exercise intervention for 18 months in the intervention group, and in the 6 month, 12 months and 18 months respectively to determine cognitive capacity the evaluation and the level of serum IGF-1. Results： cognitive ability and IGF-1 level were significantly improved in the intervention group, and there were statistically significant （P〈0.05）. Conclusion： 18 months of exer- cise intervention significantly improve serum IGF-1 level and cognitive ability of elderly patients with MCI, and show that serum IGF-1 level may be used as a marker of the effect of intervention in patients with MCI.