婴儿呼吸道合胞病毒急性下呼吸道感染的危险因素

Risk Factors of Acute Lower Respiratory Tract Infection in Infants with Respiratory Syncytial Virus

目的:探讨婴儿呼吸道合胞病毒(RSV)急性下呼吸道感染的危险因素。方法:选择2014年10月至2015年12月我院收治的急性下呼吸道感染婴儿1 480例,根据患儿呼吸道分泌物RSV检测结果分为RSV阴性组695例和RSV阳性组785例,比较两组患儿的临床资料和家庭情况,采用多因素Logistics回归分析婴儿RSV急性下呼吸道感染的危险因素。结果:RSV阳性组患儿中,低出生体质量儿、早产儿、秋冬季节感染、有基础疾病史、有先天性心脏病史、家庭常住人口≥4人、父母吸烟、母孕期合并特应性疾病的比例较高,但父母月收入≥1万元、有母孕期高血压疾病史的比例较低,与RSV阴性组比较差异均有统计学意义(P均<0.05)。Logistics回归分析显示,秋冬季节感染[OR=1.589,95%CI(1.175,2.149)]、有先天性心脏病史[OR=1.320,95%CI(1.021,1.707]、母孕期合并特应性疾病[OR=1.833,95%CI(1.229,2.734]是婴儿RSV急性下呼吸道感染的危险因素,父母月收入≥1万元[OR=0.674,95%CI(0.489,0.927]是其保护因素。结论:针对RSV急性下呼吸道感染的危险因素进行干预,可有利于预防和减少RSV急性下呼吸道感染的发生,改善预后,降低病死率。

Objective： To explore the risk factors of acute lower respiratory tract infection in infants with Respiratory syncytial virus（ RSV）. Methods： A total of 1,480 infants with acute lower respiratory tract infection in our hospital from October 2014 to December2015 were divided into RSV negative group（ 695 cases） and RSV positive group（ 785 cases） according to respiratory secretion of RSV detection. The clinical data and family status were compared. Logistic regression analysis was used to analyze the risk factors of acute lower respiratory tract infection in infants with RSV. Results： Low birth weight infants,preterm infants,autumn and winter seasons infection,underlying disease history,history of congenital heart disease,family of the resident population≥4,parental smoking,mother during pregnancy combined with atopic disease of acute lower respiratory tract infection in children had higher rate of RSV positive group,while parental smoking,parents monthly income≥10 thousands and mother during pregnancy combined with high blood pressure in children had lower rate of RSV positive（ P〈0. 05）. Logistic regression analysis showed that fall and winter seasons infection [OR =1. 589,95% CI（ 1. 175,2. 149） ],history of congenital heart disease [OR = 1. 320,95% CI（ 1. 021,1. 707） ],mother during pregnancy combined with atopic disease [OR = 1. 833,95% CI（ 1. 229,2. 734） ] were risk factors of acute lower respiratory tract infection,monthly income of parents monthly income≥10 thousands [OR = 0. 674,95% CI（ 0. 489,0. 927） ]was the protective factor.Conclusion： Execute the intervene to risk factors of acute lower respiratory tract infection in infants with RSV,can prevent and reduce RSV infection,improve the prognosis,reduce the mortality.