摘要
10^(-8)mol/L、5.5×10^(-8)mol/L、10^(-7)mol/L的硫酸吗啡使体外培养的乳鼠心肌细胞搏动频率分别增加9%、32%和81%。具有量效关系。纳络酮(10^(-5)mol/L)能完全取消吗啡的此种作用。而普萘洛尔(10^(-5)mol/L)却不影响吗啡的作用。这一结果提示吗啡可直接加快心肌细胞的搏动频率。
At the concentrations of 10-8mol/L, 5.5×l0-8mol/L, 10-7mol/L morphine produced a dose-dependent increase of beating rate in cultured rat heart cells with 9%,32%and 81% respectively. The increase was antagonized by opiate antagonist naloxone ( 10-5mol/L ) , but not affected by propranolol ( 10-5mol/L ) which could cancel the positive chronotropy of isoprenaline ( 10-9mol/L ) on the beating cells. The results support the concept that morphine may be a direct effect on myocadium, perhaps through opiate receptors.
出处
《中国药理学通报》
CAS
CSCD
北大核心
1991年第4期287-289,共3页
Chinese Pharmacological Bulletin
关键词
吗啡
心血管疾病
心肌细胞
纳络酮
Morphine
Naloxone
Cultured heart cells
Beating rate
