肠道菌群在肠道屏障功能维护中的作用和机制

The role and mechanism of intestinal flora in the maintenance of intestinal barrier function

胃肠道是重要的消化器官,其表面稳定而具有功能性的黏膜屏障是分隔机体内环境与食物抗原及微生物的生物界面。肠道菌群是定植于人体最大的微生态系统,在维持内外环境稳态中具有重要作用,肠道菌群紊乱主要体现于共生菌及病原菌的生长失衡,并与疾病的进展密切相关。越来越多的证据表明,肠道菌群作为一个完整的生态系统其组成或代谢产物影响肠道黏膜屏障结构和功能的完整性。本文就肠道菌群对肠道黏膜屏障的作用及机制进行介绍,为了解肠道微生物的研究进展提供部分参考。

The gastrointestinal tract is not only an important digestive organ but also an immune center. The stable and functional mucosal barrier is the biological surface separating internal environment and food antigen as well as microorganisms. The gastrointestinal microbiome, the largest symbiotic ecosystem colonized in the host, has been shown to play important roles in main-taining homeostasis. Dysbiosis of the gut microbiome is caused by the imbalance between the commensal and pathogenic micro-biomes, resulting in diseases development. Evidence continues to accumulate that the composition and metabolic activity of the in-testinal microbiome, as a whole community, exerts a profound influence on mucosal barrier. In this review, we briefly outline the in-teraction between the gut microbiota and the gut barrier to provide a reference for future studies.