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靶向肠道菌群代谢产物防治非酒精性脂肪性肝病 被引量:19

Microbiome-based metabolite in the treatment of patients with non-alcoholic fatty liver diseases
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摘要 非酒精性脂肪性肝病(NAFLD)是以肝脏脂质沉积为特点的慢性疾病,疾病谱包括单纯性脂肪肝、非酒精性脂肪性肝炎(NASH)及其相关肝硬化和肝细胞癌.NASH是NAFLD的严重类型,NASH相关的肝脏炎症很难自行缓解,目前尚缺乏有效的治疗手段[1].肠道菌群与宿主的代谢状况密切相关[2],肠道菌群紊乱在NAFLD的发生发展中起着重要作用[3,4].
作者 杨蕊旭 周达 范建高 YangRuixu Zhou Da Fan Jiangao.(Center for Fatty Liver Study, Department of Gastroenterology, XinHua Hospital,JiaoTong University School of Medicine, Shanghai 200092, Chin)
出处 《实用肝脏病杂志》 CAS 2017年第6期643-646,共4页 Journal of Practical Hepatology
基金 国家重点研发计划"精准医学研究"项目(编号:2017YFSF090203) 国家973课题(编号:2012CB517501) 国家自然科学基金资助项目(编号:81470840)
关键词 非酒精性脂肪性肝病 肠道菌群 益生菌 粪菌移植 Non -alcoholic fatty liver disease Gastrointestinal microbiome Probiotics Fecal microbiotatransplantation
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  • 2Masahide Hamaguchi,Takao Kojima,Noriyuki Takeda,Chisato Nagata,Jun Takeda,Hiroshi Sarui,Yutaka Kawahito,Naohisa Yoshida,Atsushi Suetsugu,Takahiro Kato,Junichi Okuda,Kazunori Ida,Toshikazu Yoshikawa.Nonalcoholic fatty liver disease is a novel predictor of cardiovascular disease[J].World Journal of Gastroenterology,2007,13(10):1579-1584. 被引量:55
  • 3Fan, JG,Li, F,Cai, XB,Peng, YD,Ao, QH,Gao, Y.Effects of nonalcoholic fatty liver disease on the development of metabolic disorders[J].中国生物学文摘,2007,21(11):21-22. 被引量:52
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