CPAP治疗对OSAHS患者血清8-isoprostane、8-OHdG水平的影响

Effect of CPAP therapy on serum level of 8-isoprostane and 8-OHdG in patients with OSAHS

目的观察OSAHS患者一夜CPAP治疗后血清8-isoprostane、8-OHdG的水平变化。方法选择经PSG检查确诊的OSAHS患者10例纳入治疗组(OSAHS组)及非OSASH患者10例纳入正常对照组(非OSAHS组),(1)比较OSAHS患者与非OSAHS患者血清8-isoprostane、8-OHdG水平差异;(2)治疗组给予夜间CPAP干预,对照比较患者予以CPAP治疗的前后血清中8-isoprostane、8-OHdG水平的变化。结果 (1)OSAHS组血清8-isoprostane、8-OHdG均高于非OSAHS组(P<0.05);(2)10例OSAHS患者经1晚CPAP治疗后血清8-isoprostane、8-OHdG水平较治疗前无显著变化(P>0.05)。结论在OSAHS患者体内存在氧化应激反应,短期的CPAP治疗对此反应无改善作用,需进行长期CPAP治疗。

Objective To observe thechanges of serum8-isoprostaneand serum 8-OHdGlevels in patientswith OSAHS,and to compare the effect of CPAP intervention on the above indexes after the treatment of OSAHS.Methods 10 non-OSASH patients were taken as the control group and 10 patients with OSAHS diagnosed by PSGas the experimental group.（1） The difference of serum 8-isoprostane and 8-OHdG levels was comcontrol group and the experimental group.（2）The experimental group was treated witli 1 night ence of serum 8-isoprostane and 8-OHdG levels prior treatment and post-treatment was compared. Results ① Theserum 8-isoprostane and 8-OHdG in the experimental group were higher thian those in the control group （P 〈0. 0 5 ） .② After 1 night treatment,serum 8-isoPG and 8-OHdG of 10 cases of OSAHS patients had no statistical significant difference than before （P〉0. 05）. Conclusion Oxidative stress occurs in OSAHS patients,of 1 night has no effect on it and it needs long term therapy.